DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20203136

Study on drug related problems in tuberculosis patients undergoing treatment

G. Ranjani, Sabushimitse Evariste, Guru Prasad Mohanta, N. Paari

Abstract


Background: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. It is one of the leading causes of mortality and morbidity around the world. The aim of this study to identify and document the drug related problems in tuberculosis patients under anti-tubercular treatment (ATT) in an attempt to promote adherence, reduce the drug related problems and improve success rate in TB treatment. The main objective of the study to identify the drug related problems in tuberculosis patients on ATT and second objective measure the medication adherence and counsel patients to improve medication adherence.

Methods: A prospective observational study was conducted in Raja Muthiah Medical College Hospital for 6 months from November 2018 to April 2019. The study was approved by Institutional Human Ethics Committee (IHEC).

Results: Total 101 drug related problems have been identified in 70 patients using pharmaceutical care network of Europe classification. Drug interactions 41.58% was the most common drug related problems found, which was clinically significant in tuberculosis patients with co- morbidities. Insufficient awareness of health and disease 21.75% was the second most common drug related problems found, 16.83% drug choice problems found. Nearly 64% of the enrolled patients were found to be non-adherence during pre-patient counselling. After the patient counselling the adherent rate was improved 74%.

Conclusions: The study concludes that pharmacist provided patient counselling found to have significant influence on improvement in the patient’s knowledge towards their disease and medication, and adherence to prescribed therapy which helps to improve the clinical outcome of TB patients.


Keywords


Drug related problem, Drug interaction, Medication adherence, Tuberculosis, Patient counselling

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References


KD Tripathi essential of medical pharmacology. 8th ed. Jaypee; 2020:815.

Nyfort K, Nahata M. A Textbook of clinical pharmacy practice. 2nd ed. orient blackswan; 2020.

Shivaraj G, Muralikrishnan, Nijeesh. study on drug related problems in tuberculosis patients with co morbidities in a tertiary care teaching hospital. EJPMR. 2017;4(9):756-67.

Karen Baxter, Stockley’s Drug Interactions, 8th Edition, Page. No: 7-388, RPS Publishing.

Farazi A, Sofian M, Jabbariasl M. Adverse reactions to antituberculosis drugs in Iranian tuberculosis patients. Tuberculosis research and treatment; 2014.

Fei CM, Zainal H, Ali I, Ali H. Evaluation of adverse drug reactions induced by anti-tuberculosis drugs in hospital pulau pinang. Malays J Med Sci. 2018;25(5):103-14.

Ramatillah DL, Nongkanga N, Suhartini S. Studied evaluation of drug related problems of the tuberculosis patients at the lung disease ward in installation of stayed caring of central general hospital persahabatan. World J Pharmaceutical Res. 2018;3(4):14-23.

Abrogoua D, Alexis B. Thierry kamenan, brou jean et al studied pharmaceutical interventions in the management of tuberculosis in a pneumophtisiology department, ivory coast, therapeutic and clinical risk management. Ther Clin Risk Manag. 2016;12:1749-56.

Gube AA, Debalkie M, Seid K, Kiberlem. Assesment of anti-TB drug nonadherence and associated factors among Tb patients attending TB clinics in Arba Minch government health institution. Tuberculosis Res Treatment. 2018:1-7.

Krishna GK, Ananthakrishnan S, Reddy T. Study on adherence to anti tuberculosis drugs under DOTs and Non-DOTs and factors affecting adherence. World J Pharmacy Pharmaceutical Sci. 2020;6(9):1973-86.