Anxiolytic activity of hydro-alcohol extract of Trema guineensis and its effect on behavioral activities of mice

Bakou Niangoran Francois; Kpahe Ziehi Fidele; Horo Yodanatchio Jules; Atayi Eugene

doi:10.18203/2319-2003.ijbcp20203134

Authors

Bakou Niangoran Francois Unit of Animal Physiology, Jean Lorougnon GUEDE University, Daloa, Cote d’Ivoire
Kpahe Ziehi Fidele Unit of Animal Physiology, Jean Lorougnon GUEDE University, Daloa, Cote d’Ivoire
Horo Yodanatchio Jules Unit of Animal Physiology, Jean Lorougnon GUEDE University, Daloa, Cote d’Ivoire
Atayi Eugene Neurology Service, Functional Exploration Unit of the Nervous System, C. H. U. from Cocody-Abidjan, Cote d’Ivoire

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20203134

Keywords:

Trema guineensis, Anxiety, Mice

Abstract

Background: Objective was to study the anxiolytic activity of hydro ethanolic extract of Trema guineensis.

Methods: Male swiss albino mice were used. Hydro ethanolic extract of Trema guineensis was administered in the doses of 5, 10 and 20 mg/kg IP hole board (HB), open field (OF), elevated plus maze (EPM) tests were used for determination of anxiolytic activity.

Results: The hydro ethanolic extract of Trema guineensis significantly increased the number and duration of head poking in HB test. The extract also significantly increased the time spent and the number of entries in open arm in EPM. In OFT, the extract showed significant increase in number of rearing, assisted rearing and the squares crossed.

Conclusions: In the present study, Trema guineensis exhibited anxiolytic activity which might be attributed to its phytoconstituents like alkaloid, steroid and triterpenes. Since Trema guineensis is ubiquitous and abundantly grown, it could be a fairly economical therapeutic agent for management of anxiety disorders.

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