A review of pharmacological effects of xylopic acid

Authors

  • Elizabeth N. Oge Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Ernest Obese Department of Pharmacology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Robert P. Biney Department of Pharmacology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Emmanuel Adakudugu Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Mary Agbenyeku Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Silas A. Osei Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Maria B. Cassera Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia
  • Ana Lisa Valenciano Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia
  • Emilio F. Merino Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia
  • Johnson N. Boampong Department of Pharmacology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast
  • Eric Woode Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi
  • Madison Adanusa University of Cape Coast Hospital, Cape Coast
  • Elvis O. Ameyaw Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20201765

Keywords:

Xylopic acid, Pain, Inflammation, CNS disorders, Infections, Xylopia aethiopica

Abstract

Xylopic acid (15β-acetyloxy-kaur-16-en-19-oic acid) is a kaurene diterpene that can be obtained from various Xylopia spp. Xylopic acid has demonstrated several pharmacological activities in vitro and in vivo. The compound has shown promising effect as a potent analgesic, anti-inflammatory and anti-allergic agent. Xylopic acid is a CNS depressant and was able to ameliorate anxiety-like symptoms in mice in addition to its neuroprotective effects. Deleterious effects of xylopic acid on the reproductive system of mice have been well documented but extensive toxicity study detailing effect of the acid upon chronic exposure needs to be determined. Due to the heavy consumption of X. aethiopica fruits, it is recommended that the pharmacokinetics of xylopic acid be determined to ascertain the possible food-drug interaction that may occur when conventional drugs are taken together with foods containing xylopic acid.

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Published

2020-04-23

How to Cite

Oge, E. N., Obese, E., Biney, R. P., Adakudugu, E., Agbenyeku, M., Osei, S. A., Cassera, M. B., Valenciano, A. L., Merino, E. F., Boampong, J. N., Woode, E., Adanusa, M., & Ameyaw, E. O. (2020). A review of pharmacological effects of xylopic acid. International Journal of Basic & Clinical Pharmacology, 9(5), 813–818. https://doi.org/10.18203/2319-2003.ijbcp20201765

Issue

Vol. 9 No. 5 (2020): May 2020

Section

Review Articles