DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20200713

Anticonvulsant activity of nicardipine in experimentally induced seizures in wistar albino rats.

Kayalvizhi M. K.

Abstract


Background: The objective of the study was to evaluate the anticonvulsant activity of nicardipine in wistar albino rats.

Methods: Anticonvulsant activity of nicardipine in a dose 10 mg/kg, and its effect with the standard drug lamotrigine (5 mg/kg) was studied in a maximal electroshock seizures (MES) experimental animal model.

Results: Nicardipine in dose of 10 mg/kg showed significant anticonvulsant effect (p<0.001) and combination with standard drug lamotrigine (p<0.001) also showed more significant anticonvulsant effect in MES model.

Conclusions: Nicardipine is having anticonvulsant activity and it also potentiates the anticonvulsant effect of lamotrigine in MES model.


Keywords


Nicardipine, Anticonvulsant, Maximal electroshock seizures, Lamotrigine

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