Potential drug-drug interactions among elderly in-patients with cardiac illness at a tertiary care centre


  • Akanksha Mathur Department of Pharmacology, AIIMS Medical College, Bhopal, Madhya Pradesh
  • Nidhi Jain Demonstrator, Gandhi Medical College, Bhopal, Madhya Pradesh
  • Achal Sharma Department of Cardiology, GSMC and KEM Hospital, Mumbai, Maharashtra
  • Prashant C. Shah Department of Pharmacology, Baroda Medical College, Vadodara, Gujarat




Cardiac, Drug interactions, Elderly, Polypharmacy


Background: Drug interactions are major cause of concern in hospitalized patients with cardiac illness especially in elderly population. Therefore, the study was conducted to determine the prevalence and pattern of potential drug-drug interactions (pDDI) and risk factors, if any.

Methods: It was a prospective observational study involving 75 elderly in-patients with cardiac diseases. IHEC approval was taken before commencement of study and written informed consent was taken from all the study participants. Data was collected using structured data collection tool. pDDI were analyzed using MEDSCAPE databse. Data was analyzed using SPSS 20.0 in terms of descriptive statistics. Pearson correlation coefficient was used to find the association between the risk factors and potential DDIs. P value of ≤0.05 was considered statistically significant.

Results: The prevalence of pDDI was found to be 100%. Total 593 pDDI and 33 interacting drug pairs were observed in the study. The common drug interacting pairs were aspirin and furosemide 140 (23.61%), followed by aspirin+ enalapril 98 (16.53%) and heparin and clopidogrel 56 (9.44%). Majority of pDDI 480 (81%) were found to be of moderate severity. A significant association was documented between length of hospital stay (p=0.041) and occurrence of pDDI. A statistically significant correlation (r =0.621; p<0.01) was noted between number of drugs prescribed and total number of pDDIs.

Conclusions: A high prevalence of pDDI was observed. The prevalence rate is directly related to number of drugs prescribed and length of hospital stay. Therefore, close monitoring of hospitalized patients is recommended.

Author Biography

Akanksha Mathur, Department of Pharmacology, AIIMS Medical College, Bhopal, Madhya Pradesh

Senior resident, Department of Pharmacology, AIIMS Bhopal


Sharma DC. Heart disease, stroke top killers in India. Available at: https://www.thehindubusinessline.com/ news/science/heart-disease-stroke-among-top-killers-in-india/article24935985.ece Accessed 24 December 2019.

Chauhan S, Aeri BT. The rising incidence of cardiovascular diseases in India: assessing its economic impact. J Preventive Cardiol. 2015;4:735-40.

Cascorbi I. Drug interactions--principles, examples and clinical consequences. Dtsch Arztebl Int. 2012;109:546-56.

Khan MZ, Sridhar SB, Gupta PK. Assessment of Potential Drug-Drug Interactions in Hospitalized Cardiac Patients of a Secondary Care Hospital in the United Arab Emirates. J Res Pharm Pract. 2019;8:20-4.

Shanbhag AD, Hema NG, Sadananda KS. Potential drug-drug interactions among hospitalized cardiac patients. Int J Basic Clin Pharmacol. 2016;5:2251-6.

Noor S, Ismail M, Ali Z. Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives? BMC Pharmacol Toxicol. 2019;20:45.

Shareef J, Menezes SL, Bhat T. A study on potential drug - drug interactions in medicine department of a multispeciality teaching hospital. J Drug Delivery Therapeut. 2017;7:81-7.

Correia RB, Kohler LPA, Mattos MM, Rocha LM. City-wide electronic health records reveal gender and age biases in administration of known drug-drug interactions. NPJ Digit Med. 2019;2:74.

Subramanian A, Adhimoolam M, Kannan S. Study of drug–drug interactions among the hypertensive patients in a tertiary care teaching hospital. Perspect Clin Res. 2018;9:9-14.

Murtaza G, Khan MY, Azhar S, Khan SA, Khan TM. Assessment of potential drug-drug interactions and its associated factors in the hospitalized cardiac patients. Saudi Pharm J. 2016;24:220-5.

Sharma S, Chhetri HP, Alam K. A study of potential drug-drug interactions among hospitalized cardiac patients in a teaching hospital in Western Nepal. Indian J Pharmacol. 2014;46:152-6.

Vonbach P, Dubied A, Krähenbühl S, Beer JH. Prevalence of drug drug interactions at hospital entry and during hospital stay of patients in internal medicine. Eur J Intern Med. 2008;19:413-20.

Aparasu R, Baer R, Aparasu A. Clinically important potential drug-drug interactions in outpatient settings. Res Social Adm Pharm. 2007;3:426-37.

Ismail M, Aziz S, Noor S, Haider I, Shams F, Haq I, et al. Potential drug-drug interactions in pediatric patients admitted to intensive care unit of Khyber teaching hospital, Peshawar, Pakistan: a cross-sectional study. J Crit Care. 2017;40:243-50.

Stoll P, Kopittke L. Potential drug-drug interactions in hospitalized patients undergoing systemic chemotherapy: a prospective cohort study. Int J Clin Pharm. 2015;37:475-84.




How to Cite

Mathur, A., Jain, N., Sharma, A., & Shah, P. C. (2020). Potential drug-drug interactions among elderly in-patients with cardiac illness at a tertiary care centre. International Journal of Basic & Clinical Pharmacology, 9(3), 470–474. https://doi.org/10.18203/2319-2003.ijbcp20200724



Original Research Articles