Study of antinociceptive effect of paroxetine in acute pain in albino rats
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20161563Keywords:
RT, SD, SSRIAbstract
Background: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. In spite of having a number of drugs like NSAIDS and opioids for the management of pain, there is still need for an ideal analgesic agent with favourable safety profile. Many studies have shown that antidepressant drugs also have analgesic activity and particularly, selective serotonin reuptake inhibitors (SSRI) are effective in mixed and chronic pain. This study was done to evaluate antinociceptive effect of Paroxetine in albino rat and to compare antinociceptive effect of Paroxetine with the standard drug pentazocine in albino rat.
Methods: Animals were divided into five groups of six each, group I as control, group II as standard whereas groups III, IV and V as test groups (three doses). Antinociceptive effect of group II pentazocine (10 mg/kg intraperitoneal) and group III, IV and V received paroxetine (2.5 mg/kg, 5 mg/kg, and 10 mg/kg bodyweight intraperitoneally respectively) was evaluated in adult albino rats by Tail flick method.
Results: Mean RT after 120 minutes of injection of Paroxetine (10 mg) was higher than baseline value of 3.42 second with, mean difference 9.55±0.45 and is significant when compared to control. No significant difference in RT was found between paroxetine 10 mg and pentazocine 10 mg. No significant difference found when baseline reading was compared with 120 minutes readings of paroxetine 2.5 group.
Conclusions: Paroxetine, a SSRI antidepressant, has a clear antinociceptive activity.
References
Russo M, Cathy M, Brose M, William G. Chronic pain. Annual review of medicine. 1998;49(1):123-33.
Becker D. Pain management in adult dental patients: the art and science of successful regimens. Practical periodontics and aesthetic dentistry. PPAD. 1996;8:1.
Oxenham D. Davidson’s principles and practice of medicine. 21st ed: Churchill Livingstone Elsevier; 2010:280.
Guyton AC, Hall JE. Text book of medical physiology. 10th ed: Philadelphia: Sauders; 2000:552.
Fields HL, Martin JB. Pain pathophysiology and management. In: Harrison’s Principles of Internal Medicine. 17th ed.: Volume I; McGraw-Hill Companies, United States of America; 2007:81-86.
Vogel HG, Vogel WH, Schölkens BA, Sandow J, Müller PDG, Vogel WF. Analgesic, anti-inflammatory, and anti-pyretic activity. Drug Discovery and Evaluation: Springer; 2002:670-773.
Lowensten DH. Pain: pathophysiology and management. In: Fields HL, Martin JB edts Harrisons principles of internal medicine. 16th edn, Volume I, Unite states of America: Mc Graw Hills Companies; 2005:7.
Elhwuegi AS, Hassan KM. The analgesic effect of different antidepressants combined with aspirin on thermally induced pain in Albino mice. Libyan Journal of Medicine. 2012;7(1):17251.
Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. Journal of general internal medicine. 1997;12(6):384-9.
Yokogawa F, Kiuchi Y, Ishikawa Y, Otsuka N, Masuda Y, Oguchi K, et al. An investigation of monoamine receptors involved in antinociceptive effects of antidepressants. Anesthesia and analgesia. 2002;95(1):163-8.
Duman EN, Kesim M, Kadioglu M, Yaris E, Kalyoncu NI, Erciyes N. Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain. Journal of pharmacologi al sciences. 2004;94(2):161-5.
Richelson E, editor. Pharmacology of antidepressants. Mayo Clinic Proceedings; Elsevier. 2001;76:511-27.
Kanai A, Hoka S. Analgesic and antidepressive effect of paroxetine in patients with refractory chronic pain. Anaesthesiol. 2005;103:753.
Masand PS, Narasimhan M, Patkar AA. Paroxetine for somatic pain associated with physical illness: a review. Primary care companion to the Journal of clinical psychiatry. 2006;8(3):122-30.
Gray A, Spencer P, Sewell R. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. British journal of pharmacology. 1998;124(4):669-74.
Gray AM, Pache DM, Sewell RD. Do α2 adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds? European journal of pharmacology. 1999;378(2):161-8.
Ghosh MN. Fundamentals of Experimental Pharmacology. 4th ed. Kolkata: Ghosh SK; 2008:73.
Turner RA. Analgesics in: screening methods in pharmacology; Academic press Newyork London; 1985.
Rao KV. Biostastics a manual of statistical mehods for use in health, nutrition and anthropology.1st edn, Mumbai: Jaypee; 1996:237,278.
Erdem DN, Murat K, Mine K, Cunay U, Nuri KI, Ersin Y. Effect of gender on antinociceptive effect of paroxetine in hot plate test in mice. Prog neuro psychopharmacol Biol Psychatr. 2006;30(2):292-6.
Masand PS, Narasimhan M, Patkar AA. Paroxetine for somatic pain associated with physical illness: A review. Prim Care Companion J Clin Psychiatry. 2006;8:122-30.
