Efficacy of orlistat in the treatment of patients with non-alcoholic fatty liver

Manouchehr Iranparvar Alamdari; Shahram Habibzadeh; Ahad Azami; Babak Shirinzadeh; Roghayeh Aslanian; Kiana Yazdanbod

doi:10.18203/2319-2003.ijbcp20200179

Authors

Manouchehr Iranparvar Alamdari Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Science, Ardabil, Iran
Shahram Habibzadeh Department of Infectious Disease, Imam Khomeini Hospital, Ardabil University of Medical Science, Ardabil, Iran
Ahad Azami Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Science, Ardabil, Iran
Babak Shirinzadeh Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Roghayeh Aslanian Department of Biochemistry, Ghaem Hospital, Ardabil University of Medical Science, Ardabil, Iran
Kiana Yazdanbod Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20200179

Keywords:

Ardabil, Fatty liver, Orlistat

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a reversible condition of fat accumulation that is associated with liver inflammation and can disrupt the normal activity of the liver. People with a diagnosis of NAFLD have a higher risk of all- cause mortality than the general population. The purpose of the present study was to determine, the efficacy of orlistat in the treatment of patients with NAFLD.

Methods: This semi-experimental study was performed on 45 fatty liver patients of the gastroenterology clinic of Imam Khomeini Hospital in Ardabil city in April 2016 to April 2017. Data was collected by a checklist which included demographic and clinical data such as age, sex, body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), cholesterol and result of ultrasound before and after orlistat consumption.

Results: The mean decrease in the variables examined was as follows: weight 8.3 kg, BMI 3.5 kg/m², ALT 31.6 U/l, AST 18.1 U/l, cholesterol 15.5 mg/dl and TG 33.1 mg/dl. All of the upper indexes were decreased significantly following received drug.

Conclusions: Orlistat therapy was associated with significant decreases in ALT, AST, TG and cholesterol level. Orlistat is effective in weight loss, body mass index reduction and can be used to treat non-alcoholic fatty liver disease.

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