Potentiation of general anaesthetic activity of ketamine by memantine

M. S. Umamageswari; K. Vasanthan; T. M. Karthikeyan

doi:10.18203/2319-2003.ijbcp20195777

Authors

M. S. Umamageswari Department of Pharmacology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India
K. Vasanthan Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
T. M. Karthikeyan Department of Pathology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20195777

Keywords:

Ketamine, Memantine, General anaesthesia

Abstract

Background: The study was done with the objective to evaluate synergistic activity of ketamine induced general anesthesia by memantine in wistar albino rats.

Methods: The wistar albino rats of either sex were divided into four groups of five animals. Group 1 received ketamine 40 mg/kg, group 2 received ketamine 80 mg/kg, group 3 received ketamine 40 mg/kg along with memantine 10 mg/kg and group 4 received 80 mg of ketamine along with memantine 10 mg/kg to evaluate the synergistic activity of ketamine induced general anesthesia by memantine. The sleep latency time and duration of sleep were measured in all the groups.

Results: The sleep latency time of group 4 is significantly decreased (p<0.001) compared to all other groups. The duration of sleep of group 4 is significantly increased (p<0.001) compared to group 1 and group 3, but less than that of group 1.

Conclusions: Memantine possess synergistic activity of ketamine induced general anaesthesia.

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Author Biographies

M. S. Umamageswari, Department of Pharmacology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India

Associate Professor, Department of Pharmacology

T. M. Karthikeyan, Department of Pathology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India

Professor and Head, Department of Pathology

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