Evaluation of differences in health-related quality of life in patients receiving conventional versus newer anti-epileptic drugs


  • Kavisha S. Goswami Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India
  • Devang A. Rana Department of Pharmacology,Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India
  • Shalin Shah Department of Neurology, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India
  • Supriya D. Malhotra Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India




Drug use pattern, Epilepsy, Quality of life, HR-QOL, Prescription pattern


Background: Epilepsy is associated with stigma and bad health-related quality of life (HR-QOL) due to this, and side effects of the drug therapy. Newer anti-epileptics are claimed to be better than the conventional. We evaluated this based on comparison of HR-QOL in patients taking the respective therapy.

Methods: An observational, cross-sectional, single point study involved 127 consenting patients from Neurology OPD at V.S. General Hospital. Quality of life in epilepsy-10 (QOLIE-10) questionnaire was used to measure HR-QOL in patients. SPSS software and Graphpad prism were used to analyze the variables.

Results: Patients of 20-30 age group were commonly affected (37.80%) with a male predominance (56.69%). 41.73% were unemployed. The difference in HR-QOL between patients and controls in all three domains (epilepsy effects, mental effects, role function domains) of QOLIE-10 was significant (p=0.0002), indicating better HR-QOL in controls. The worst HR-QOL scores were found in Epilepsy effects domain. Metabolic adverse effects (38.58%) were the common ADRs. Sodium valproate was the most effective in controlling seizures (last seizure episode: 15 months). HR-QOL correlation between patients receiving monotherapy and polytherapy was significant (p=0.026) with monotherapy rendering a better HR-QOL. Comparison of HR-QOL between patients taking the conventional and the newer drugs was not significant (p=0.1768).

Conclusions: Our study nullifies the claims that newer drugs are better than the conventional since no such benefit was seen in HR-QOL as well as ADRs. Our findings ruled out the belief that cases of epilepsy are better controlled with polytherapy.


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How to Cite

Goswami, K. S., Rana, D. A., Shah, S., & Malhotra, S. D. (2020). Evaluation of differences in health-related quality of life in patients receiving conventional versus newer anti-epileptic drugs. International Journal of Basic & Clinical Pharmacology, 9(2), 342–347. https://doi.org/10.18203/2319-2003.ijbcp20200188



Original Research Articles