Neurotransmitters and neuromodulators involved in learning and memory
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20195296Keywords:
Learning, Memory, Attention, Neurotransmitters, NeuromodulatorsAbstract
Learning and memory being highly specialized process of human brain involves complex interaction between neurotransmitters and cellular events. Over the years, the understandings of these processes have been evolving from psychological, neurophysiological, and pharmacological perspectives. The most widely appraised model of learning and memory involves attention, acquisition, storage and retrieval. Each of these events involve interplay of neurotransmitters such as dopamine, acetylcholine, norepinephrine, N-methyl-d-aspartic acid, gamma-aminobutyric acid, though preponderance of specific neurotransmitter have been documented. The formation of long-term memory involves cellular events with neuroplasticity. Further, dopamine is documented to play crucial role in the process of forgetting. Understanding of the processes of learning and memory not only facilitates drug discovery, but also helps to understand actions of several existing drugs. In addition, it would also help to enhance psychological interventions in children with learning disabilities. Thus, the review intends to summarize role of neurotransmitters and neuromodulators during different phases of learning and memory.Metrics
References
Kolb DA. Experiential learning: Experience as the source of learning and development. Englewood Cliffs, United States: NJ: Prentice-Hall; 1984: 288.
Atkinson RC, Shiffrin RM. Human memory: a proposed system and its control processes. In: Spence KW, Spence JT, eds. The psychology of learning and motivation. New York, NY: Academic Press; 1968: 89–195.
Goelet P, Castellucci VF, Schacher S, Kandel ER. The long and the short of long-term memory--a molecular framework. Nature. 1986;322:419-22.
Vianna MR, Izquierdo LA, Barros DM, Walz R, Medina JH, Izquierdo I. Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades. An Acad Bras Cienc. 2000;72:353-64.
Izquierdo I, Medina JH. Memory formation: the sequence of biochemical events in the hippocampus and its connections to activity in other brain structures, Neurobiol Learn Mem. 1997;68:285-316.
Ardenghi P, Barros D, Izquierdo LA, Bevilaqua L, Schröder N, Quevedo J, et al. Late and prolonged memory modulation in entorhinal and parietal cortex by drugs acting on the cAMP/protein kinase. A signalling pathway. Behav Pharmacol 1997;8:745-51.
Hnasko TS, Edwards RH. Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol 2012;74:225-43.
Ma S, Hangya B, Leonard CS, Wisden W, Gundlach AL. Dual-transmitter systems regulating arousal, attention, learning and memory. Neurosci Biobehav Rev. 2018;85:21-33.
Bartus RT, Dean RL, Pontecorvo MJ, Flicker C. The cholinergic hypothesis: a historical overview, current perspective, and future directions. Ann NY Acad Sci. 1985;444:332–58.
Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol. 2006;16:710-5.
Wisman LA, Sahin G, Maingay M, Leanza G, Kirik D. Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory. J Neurosci. 2008;28:7797-807.
Ellis KA, Nathan PJ. The pharmacology of human working memory. Int. J Neuropsychopharmacol. 2001;4:299–313.
Matsumoto N, Hanakawa T, Maki S, Graybiel AM, Kimura M. Nigrostriatal Dopamine System in Learning to Perform Sequential Motor Tasks in a Predictive Manner. J Neurophysiol. 1999;82:978-98.
Mele A, Avena M, Roullet P, De Leonibus E, Mandillo S, Sargolini F, et al. Nucleus accumbens dopamine receptors in the consolidation of spatial memory. Behav Pharmacol. 2004;15:423-31.
Miendlarzewska EA, Bavelier D, Schwartz S. Influence of reward motivation on human declarative memory. Neurosci Biobehav Rev. 2016;61:156-76.
Nakajima S, Gerretsen P, Takeuchi H, Caravaggio F, Chow T, Le Foll B, et al. The potential role of dopamine D₃ receptor neurotransmission in cognition. Eur Neuropsychopharmacol. 2013;23:799-813.
Berry JA, Cervantes-Sandoval I, Nicholas EP, Davis RL. Dopamine is required for learning and forgetting in Drosophila. Neuron. 2012;74:530-42.
Awata H, Takakura M, Kimura Y, Iwata I, Masuda T, Hirano Y. The neural circuit linking mushroom body parallel circuits induces memory consolidation in Drosophila. Proc Natl Acad Sci. 2019:201901292.
Bliss TVP, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol. 1973;232:331.
Villarreal D, Do V, Haddad E, Derrick BE. NMDA antagonists sustain LTP and spatial memory: evidence for active processes underlying LTP decay. Nat Neurosci. 2002;5:48.
Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 5th ed. Sydney: Churchill Livingstone; 2003: 315–322.
Schummers J, Browning MD. Evidence for a role for GABA(A) and NMDA receptors in ethanol inhibition of long-term potentiation. Brain Res Mol Brain Res. 2001;94:9-14.
Heaney CF, Kinney JW. Role of GABA(B) receptors in learning and memory and neurological disorders. Neurosci Biobehav Rev 2016;63:1-28
Zyablitseva EA, Kositsyn NS, Shul'gina GI. The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning. Span J Psychol. 2009;12:12-20.
Martinez JL, Nasquez BJ, Rigler H. Attenuation of amphetamine induced enhancement of learning by adrenal demodulation. Brain Res. 1980;195:433-43.
Chamberlain SR, Robbins TW. Noradrenergic modulation of cognition: therapeutic implications. J Psychopharmacol. 2013;27:694-718.
Strange BA, Dolan RJ. Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses. Proc Natl Acad Sci U S A. 2004;101:11454-8.
Buhot MC, Martin S, Segu L. Role of serotonin in memory impairment. Ann Med. 2000;32:210-21.
Cassel JC, Jeltsch H. Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neurosci. 1995;69:1-41.
Seyedabadi M, Fakhfouri G, Ramezani V, Mehr SE, Rahimian R. The role of serotonin in memory: interactions with neurotransmitters and downstream signaling. Exp Brain Res. 2014;232:723-38.
Mochizuki T, Yamatodani A, Okakura K, Horii A, Inagaki N, Wada H. Circadian rhythm of histamine release from the hypothalamus of freely moving rats. Physiol Behav. 1992;51:391-4.
Fabbri R, Furini CR, Passani MB, Provensi G, Baldi E, Bucherelli C, et al. Memory retrieval of inhibitory avoidance requires histamine H1 receptor activation in the hippocampus. Proc Natl Acad Sci U S A. 2016;113:e2714-20.
Köhler CA, da Silva WC, Benetti F, Bonini JS. Histaminergic mechanisms for modulation of memory systems. Neural Plast. 2011:328602.
Bekkers JM. Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus. Science. 1993; 261:104-6.
Frey U, Huang YY, Kandel ER. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science. 1993;260:1661-4.
Feil R, Kleppisch T. NO/cGMP-dependent modulation of synaptic transmission. Handb Exp Pharmacol. 2008;184:529-60.
Zhuo M, Hawkins RD. Long-term depression: a learning related type of synaptic plasticity in the mammalian central nervous system. Rev Neurosci. 1995;6:259–77.
Ben Aissa M, Lee SH, Bennett BM, Thatcher GR. Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease. Curr Med Chem. 2016;23:2770-88.
Ogren SO, Kuteeva E, Elvander-Tottie E, Hökfelt T. Neuropeptides in learning and memory processes with focus on galanin. Eur J Pharmacol. 2010;626:9-17.
Riley AL, Zellner DA, Duncan HJ. The role of endorphins in animal learning and behavior. Neurosci Biobehav Rev. 1980;4:69-76.
Adem A, Madjid N, Kahl U, Holst S, Sadek B, Sandin J, et al. Nociceptin and the NOP receptor in aversive learning in mice. Eur Neuropsychopharmacol. 2017;27:1298-307.
Goeldner C, Reiss D, Wichmann J, Kieffer BL, Ouagazzal AM. Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms. Neurobiol Learn Mem. 2009;91:393–401.
Fernández-Ruiz J, Berrendero F, Hernández ML, Ramos JA. The endogenous cannabinoid system and brain development. Trends Neurosci. 2000;23:14-20.
Covelo A, Araque A. Lateral regulation of synaptic transmission by astrocytes. Neurosc. 2016;323:62–6.
Kruk-Slomka M, Dzik A, Budzynska B, Biala G. Endocannabinoid System: the Direct and Indirect Involvement in the Memory and Learning Processes-a Short Review. Mol Neurobiol. 2017;54:8332-47.
Poo MM. Neurotrophins as synaptic modulators. Nat Rev Neurosci. 2001;2:24-32.
Cotman CW, Berchtold NC, Christie LA Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30:464-72.
Liu-Ambrose T, Nagamatsu LS, Voss MW, Khan KM, Handy TC. Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol Aging. 2012;33:1690-8.
Borbély E, Scheich B, Helyes Z. Neuropeptides in learning and memory. Neuropeptides. 2013;47:439-50.
Yamada K, Mizuno M, Nabeshima T. Role for brain-derived neurotrophic factor in learning and memory. Life Sci. 2002;70:735-44.
Mayne PE, Burne THJ. Vitamin D in synaptic plasticity, cognitive functions and neuropsychiatric illness. Trends Neurosci. 2019;42:293-306.
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