Sociodemographic and drug prescription pattern in patients with rheumatoid arthritis in a tertiary care teaching hospital

Authors

  • Vijoy Sankar Kairi Department of Pharmacology, Silchar Medical College, Silchar, Assam, India
  • Sarajita Barman Department of Pharmacology, Silchar Medical College, Silchar, Assam, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20195769

Keywords:

Rheumatoid arthritis, Housewives, DMARDs, Sulfasalazine

Abstract

Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease that affects mainly the small joints of the hands and feet. RA is widely prevalent throughout the world.

Methods: A prospective and observational study was carried out on 44 patients for 6 months. Patients of either sex, aged between 18 to 70 years diagnosed with rheumatoid arthritis were screened and recruited in the study. Patients were diagnosed on the basis of clinical assessment and the lab parameters assessed were rheumatoid factor and anti-CCP (anti-cyclic citrullinated peptide antibody). Prescriptions were analyzed for socio-demographic details and drug prescribing pattern.

Results: Out of 44 patients, 36 (81.82%) were females, 8 (18.18%) were males. Maximum occurred 19 (43.18) between 31 to 40 years of age. Out of 19 (43.18%), females were 16 (36.36%), males were 3 (6.83%). 39 (88.63%) were from rural and 5 (11.37%) from urban area, 21 (47.73%) illiterate, 15 (34.09%) primary educated, 7 (15.91%) secondary educated, 1 (2.27%) educated above higher secondary, 4 (9.08%) unemployed, 2 (4.55%) students, 19 (43.18%) housewives, 7 (15.91%) agricultural workers, 7 (15.91%) non-agricultural outdoor workers and 5 (11.37%) non-agricultural indoor workers. Most common co-morbidity was hypertension 28 (63.63%). Anti-CCP was positive in 38 (86.36%). All of the patients 44 (100%) received disease-modifying anti-rheumatic drugs (DMARDs). Majority of the patients were prescribed with triple DMARDs combination 30 (68.18%).

Conclusions: We observed that female were dominant over the male with male: female ratio of 1: 4.5. Prescriptions pattern was primarily based on DMARDs.

References

Prabha ML, Rani AG, Balasubramanian M, Ramya JE. Prescribing pattern and adverse drug reactions monitoring in patients with rheumatoid arthritis in a tertiary care hospital. Int J Basic Clin Pharmacol. 2016;5(3):805-9.

Liao PK, Alfredsson L, Karlson WE. Environmental influences on risk for rheumatoid arthritis. Curr Opin Rheumatol. 2009;21(3):279-83.

Singh JA, Saag KG, Bridges SL Jr, Akl EA, Bannuru RR, Sullivan MC, et al. American College of Rheumatology Guideline for the Treatment of Rheumatoid. Arthritis. Arthritis Rheumatol. 2016;68(1):1-26.

Dahiya A, Kalra BS, Saini A, Tekur U. Prescription pattern in patients with rheumatoid arthritis in a teaching tertiary care hospital. MAMC J Med Sci. 2016;2(1):33-7.

Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2:119-25

Moura MG, Lopes LC, Silva MT, Filho SB, Motta RHL, Bergamaschi C. Use of steroid and nonsteroidal anti-inflammatories in the treatment of rheumatoid arthritis. Medicine. (2018);97(41):e12658.

Misra R, Sharma BL, Gupta R, Pandya S, Agarwal S, Agarwal P, et al. Indian Rheumatology Association consensus statement on the management of adults with rheumatoid arthritis. Indian J Rheumatol. 2008;3(3):1-16.

Shini VK, Aboobacker S, Pahuja S, Revikumar KG, Bhasi R. Pharmacoeconomic study of DMARDs in the management of rheumatoid arthritis. Int J Pharma Sci Rev Res. 2010;5(3):148-54.

Mittal N, Mittal R, Sharma A, Jose V, Wanchu A, Singh S. Treatment failure with disease-modifying antirheumatic drugs in rheumatoid arthritis patients. Singapore Med J. 2012;53(8):532-6.

Aletaha D, Smolen JS. The rheumatoid arthritis patient in the clinic: comparing more than 1300 consecutive DMARD courses. Rheumatology. 2002;41(12):1367-74.

Singh AV, Malaviya AN, Kumar S. Characteristics of rheumatoid arthritis patients at first presentation to a specialized rheumatology department. Int J Res Med Sci. 2015;3(8):2073-8.

Kasper DL, Hauser SL, Jamesson JL, fauci AS Longo DL, Loscalzo J. Harrison’s Principle of Internal Medicine. 19th Edition. USA: McGraw Hill Education; 2015.

Bajraktari IH, Teuta BÇ, Vjollca SM, Bajraktari H, Saiti V, Krasniqi B, et al. Demographic Features of Patients with Rheumatoid Arthritis in Kosovo. Med Arch. 2014;68(6):407-10.

Handa R, Rao U.R.K, Lewis J.F.M, Rambhad G, Shiff S, Ghia CJ. Literature review of rheumatoid arthritis in India. Int J Rheumatic Dis. 2016;19:440-51.

Kashefi S, Lee SM, Mallaysamy S, Thunga G. Demographic, clinical characteristics and drug prescription pattern in patients with rheumatoid arthritis in south Indian tertiary care hospital. Int J Phrm Sci. 2016;8(8):251-7.

Lee YH. Effect of Formal Education Level on Measurement of Rheumatoid Arthritis Disease Activity. J Rheumatic Dis. 2015;22(5):271-3.

Bal A, Ataman S, Bodur H, Rezvani A, Paker N, Tastekin N. Characteristics of Patients With Rheumatoid Arthritis in Turkey: Results From the Turkish League Against Rheumatism Rheumatoid Arthritis Registry. Arch Rheumatol. 2015;30(1):16-22.

Jebastine MI, Nasmi N, Elias N, Neethu VV, Arul B. Prescription pattern of drugs used in management of rheumatoid arthritis in a tertiary care hospital: A retrospective study. Indo Am J Pharm Sci. 2015;2(8):1198-205.

Chakravarty K, McDonald H, Pullar T, Taggart A, Chalmers R, Oliver S, et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatology (Oxford). 2008;47(6):924-5.

Suresh E, Lambert CM. Combination treatment strategies in early rheumatoid arthritis. Ann Rheum Dis. 2005;64(9):1252-56.

Gurung S, Babu S, Sabu S, Shibu RM, Begum R, Nanjwade BK. A study on prescribing pattern in the management of osteoarthritis and rheumatoid arthritis in the department of orthopaedics. World J Pharmacy Pharma Sci. 2016;5(4):1472-93.

Kumar P, Banik S. Pharmacotherapy Options in Rheumatoid Arthritis. Clin Med Insights Arthritis Musculoskelet Disord. 2013;6(6):35-43.

Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA, et al. Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007;115:1634-42.

Smolen JS, Landewe R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis. 2014;73:492-509.

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Published

2019-12-24

How to Cite

Kairi, V. S., & Barman, S. (2019). Sociodemographic and drug prescription pattern in patients with rheumatoid arthritis in a tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology, 9(1), 96–100. https://doi.org/10.18203/2319-2003.ijbcp20195769

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Original Research Articles