Antidiabetic effect of Pterocarpus marsupium seed extract in gabapentin induced diabetic rats


  • Sivanageswararao Mekala Department of Pharmacology and Head of Allied Health Sciences, The State University of Zanzibar, Tanzania
  • Salum Seif Salum Mchenga Department of Pathology, School of Health and Medical Sciences, The State University of Zanzibar, Tanzania
  • Saravanan R. Department of Pharmacology, RVS Dental College and Hospital, Coimbatore, Tamilnadu, India



Diabetes mellitus, Gabapentin, Metformin, Pterocarpus marsupium


Background: Type 2 diabetes mellitus is the most common type of diabetes. Diabetes mellitus is a leading cause of morbidity and mortality among Indian population and all over the world with more than hundreds of millions of patients worldwide. Pterocarpus marsupium is a medicinal plant used in Ayurvedic system of medicine to control blood sugar and strong antidiabetic. The purpose of this study was to assess the hypoglycemic effect of the ethanolic extract of Pterocarpus marsupium seeds in diabetic rats.

Methods: The present work was designed to evaluate the anti-hyperglycaemic activity of Pterocarpus marsupium seed extract (100 mg/kg and 200 mg/kg) on gabapentin induced hyperglycaemia in wistar albino rats. Blood glucose level, serum triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol were evaluated in gabapentin induced diabetic rats. The results of the test drug were compared with the standard drug.

Results: Ethanolic seed extract of Pterocarpus marsupium at 100 mg/kg and 200 mg/kg had significantly reduced the blood glucose level compared to disease control rats on day 1, 7, 14 and 21. Pterocarpus marsupium shows significant decrease in triglycerides levels, serum cholesterol levels, LDL levels and increased HDL levels, total protein levels compared to the disease control group.

Conclusions: In conclusion, the present study shows that the ethanolic seed extract of Pterocarpus marsupium has potential antidiabetic action in gabapentin induced diabetic rats and the effect was found to be more similar to the standard drug metformin.


Kirkham S, Akilen R, Sharma S, Tsiami A. The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance. Diabetes, Obesity Metab. 2009;11(12):1100-3.

Patil UH, Dattatraya KG. Pterocarpus marsupium: a valuable medicinal plant in diabetes management. Int J App Bio Pharm Tech. 2011;2:6-13.

Waghmare AS, Waghmare PD, Grampurohit ND, Gadhave MV. Free radical scavenging activity of methanolic and aqueous extract of Pterocarpus marsupium heartwood by DPPH method. J Sci Res Phar. 2012;1:89-91.

Hilal A, Kalyanaraman R. Pharmacology of Pterocarpus marsupium Roxb. Med Plant Res. 2015;5:1-6.

Vats V, Grover JK, Rathi SS. Evaluation of antihyperglycemic and hypoglycemic effect of Trigonellafoenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanizeddiabetic rats. J Ethnopharmacol. 2002;79:95-100.

Karanjit N, Shrestha UK, Ranjitkar RR. A study on hypoglycemic properties of Pterocarpus marsupiumRoxb. Bullet Dept Plant Res. 2008;30:97-101.

Manickam M, Ramanathan M, Jahromi MA, Chansouria JP, Ray AB. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod. 1997;60:609-10.

Jahromi MA, Ray AB. Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. J Nat Prod. 1993;56(7):989-94.

Mishra A, Srivastava R, Srivastava SP, Gautam S, Tamrakar AK, Maurya R, et al. Antidiabetic activity of heart wood of Pterocarpus marsupiumRoxb. and analysis of phytoconstituents. Ind J Experiment Biol. 2013;51:363-74.

Chakravarthy BK, Gupta S, Gambhir SS, Gode KD. Pancreatic beta-cell regeneration- A novalantidiabetic mechanism of Pterocarpus marsupium, Roxb., Indian J Pharmac. 1980;12:123-4.

Ahmad F, Khalid P, Khan MM, Rastogi AK, Kidwai JR. Insulin like activity in (-)-epicatechin. Acta Diabetologica Lat. 1989;26:291.

Chakravarthy BK, Gupta S, Gambhir SS, Gode KD. The prophylactic action of (−)-epicatechin against alloxan induced diabetes in rats. Life Sci. 1981;29(20):2043-7.

Philip S. Flexible dose open trial of Vijayasar in cases of newly-diagnosed non-insulin-dependent diabetes mellitus. Indian Council of Medical Research (ICMR), Collaborating Centres, New Delhi. Ind J Med Res. 1998;108:24-9.

Langham DR. Growth and development of sesame. Sesaco Corp. 2008: 329.

Zohary D, Hopf M, Weiss M. Domestication of Plants in the Old World: The Origin and Spread of Cultivated Plants in West Asia, Europe, and the Nile Valley. Oxford University Press. 2000

Oplinger ES, Putnam DH, Kaminski AR, Hanson CV, Oelke EA, Schulte EE, et al. Sesame. Available at: html. Accessed on 02 December 1997.

Noon DD. Sesame Oil Benefits Blood Pressure Cooking Oil Switch May Be High Blood Pressure Treatment. Inter-Am Soc Hypertension. 2003.

Srikanth M, Rao GV, Rao KS. Modified assay procedure for the estimation of serum glucose using microwell reader. Ind J Clini Biochem. 2004;19(1):34-5.

Penumarthy S, Penmetsa GS, Mannem S. Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients. J Indian Soc Periodontol. 2013;17(1):30-5.

George RK, Kingsley R. Determination of serum total protein, albumin, and globulin by the biuret reaction. J Biol. Chem. 1939;131:197-200.

Mishra A, Srivastava R, Srivastava SP, Gautam S, Tamrakar AK, Maurya R, Srivastava AK. Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb and analysis of phytoconstituents. Indian J Exp Biol. 2013;51(5):363-74.

Abhishek N, Hegde K, Chaithra Amin B, Kumar A. Evaluation of antidiabetic activity of ethanolic extract of roots of Pterocarpus marsupium in streptozotocin induced diabetic rats. J Pharmaceut Biol Sci. 2017;5(4):145-9.

Maruthupandian A, Mohan VR. Antidiabetic, Antihyperlipidaemic and Antioxidant activity of Pterocarpus marsupium Roxb. in alloxan induced diabetic rats. Inter J Pharm Tech Res. 2011;3(3):1681-87.

Perera HK. Antidiabetic effects of Pterocarpus marsupium (Gammalu). Europ J Med Plants. 2016:13(4):1-14.




How to Cite

Mekala, S., Mchenga, S. S. S., & R., S. (2020). Antidiabetic effect of Pterocarpus marsupium seed extract in gabapentin induced diabetic rats. International Journal of Basic & Clinical Pharmacology, 9(3), 371–377.



Original Research Articles