Efficacy evaluation of antidepressant drugs utilized at tertiary care centre in North Karnataka in psychiatric outpatient department

Authors

  • Harish G. Bagewadi Department of Pharmacology, Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka
  • Chandrashekar B. Huded Department of Psychiatry, Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20194785

Keywords:

Depression, Antidepressant, Monotherapy

Abstract

Background: Depression is the major psychotic disorder affecting 9.5% of population worldwide. Present study investigates the prescribing patterns of different antidepressants evaluating their efficacy.

Methods: This was a prospective, observational study which was conducted in the out-patient department of Psychiatry and Pharmacology in Gulbarga Institute of Medical Sciences, Kalaburagi. A total of 200 cases were enrolled for the present study. Statistical analysis for efficacy was done using Wilcoxson’s signed rank test.

Results: Predominantly, females suffered from depression when compared to male counterparts. In our study, monotherapy was practiced more frequently than polytherapy with 2 or more drugs. Selective serotonin reuptake inhibitors (SSRIs) like Escitalopram was found out to be the most widely used antidepressant drug.

Conclusions: Among antidepressant medications, SSRIs are preferred over others because of their better side effect profile.

References

Jayanthi CR, Divyashree M, Sushma M. Adverse drug reactions in psychiatry outpatients: Clinical spectrum, causality and avoidability. J Chem Pharm Res. 2013;5(8):128-35.

Ray S, Chogtu B. Prescribing trends in depression: a drug utilization study done at a tertiary healthcare centre. J Clin Diagn Res. 2011;5(3):573-7.

Reddy MS. Depression: the disorder and the burden. Indian J Psychol Med. 2010;32:1-2.

Pincus HA, Tanielian TL, Marcus SC, Olfson M, Zarin DA, Thompson J, et al. Prescribing trends in psychotropic medications: primary care, psychiatry, and other medical specialities. JAMA. 1998;279:526-31.

Olfson M, Marcus SC, Druss B, Elinson L, Tanielian T, Pincus HA, et al. National trends in the outpatient treatment of depression. JAMA. 2002;287:203-9.

Ray S, Chogtu B. Prescribing Trends in Depression - A drug utilization study done at a tertiary healthcare centre. JCDR. 2011;5:573-7.

Sengupta G, Bhowmick S, Hazra A, Datta A, Rahaman M. Adverse drug reaction monitoring in psychiatry out-patient department of an Indian teaching hospital. Indian J Pharmacol. 2011;43:1:36-9.

Hedlund JL, Viewig BW. The Hamilton rating scale for depression: a comprehensive review. J Operational Psychiatr. 1979;10:149-65.

Hamilton M. Development of a rating scale for Primary Depressive Illness. Br Soc Clin Psychol. 1967;6(4):278-96.

Williams JBW. A structured interview guide for the Hamilton Depression Rating Scale. Arch General Psychiatr. 1989;45:742-7.

Demyttenaere K, De Fruyt J. Getting what you ask for: on the selectivity of depression rating scales. Psychother Psychosom. 2003;72:61-70.

Williams JB. Standardizing the Hamilton Depression Rating Scale: past, present, and future. Eur Arch Psychiatry Clin Neurosci. 2001;251(suppl 2):II6-II12.

Hedlund JL, Vieweg BW. The Hamilton Rating Scale for Depression: a comprehensive review. J Operational Psychiatr. 1979;10:149-65.

Bech P. Rating scales for affective disorders: their validity and consistency. Acta Psychiatr Scand Suppl. 1981;295:1-101.

Morabia A, Fabre J, Dunand JP. The influence of patient and physician gender on the prescription of psychotropic drugs. J Clin Epidemiol. 1992;45:111-6.

The ESEMeD/MHEDEA 2000 investigators. Psychotropic drug utilization in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand. 2004;109:55-64.

Uchida N, Chong MY, Tan CH, Nagai H, Tanaka M, Lee MS, et al. International study on antidepressant prescription pattern at 20 teaching hospitals and major psychiatric institutions in East Asia:Analysis of 1898 cases from China, Japan, Korea, Singapore and Taiwan. Psychiatr Clin Neurosci. 2007;61:522-8.

Chaturvedi R, Sharma P. Drug utilization study of psychotropic drugs prescribed in psychiatry OPD of L. N. medical college associated J. K. hospital, Bhopal district, Madhya Pradesh. J Evol Med Dent Sci. 2016;5(51):3242-4.

Chong M, Tan C, Fujii S, Yang S, Ungvari G, Tianmei SI, et al. Anti-psychotic drug prescription for schizophrenia in East Asia: Rationale for change. Psychiar Clin Neurosci. 2004;58:61-7.

Cuevas C, Sanz EJ. Polypharmacy in psychiatric practice in Canary Islands. BMC Psychiatr, 2004;4:1-8.

Mortimer A, Shepherd C, Rymer M, Burrows A. Primary care use of antipsychotic drugs: an audit and intervention study. Ann General Psychiatr. 2005;4:1-8.

Kingshuk Lahon, Harsha M. Shetty, Amith Paramel, Gyaneswar Sharma. A Retrospective Drug Utilization Study of Antidepressants in the Psychiatric Unit of a Tertiary Care Hospital. J Clin Diagnos Res. 2011;5(5):1069-75.

Mishra S, Swain T, Mohanty M. Patterns of prescription & efficacy evaluation of antidepressants in a tertiary care teaching hospital in eastern India. Asian J Pharm Clin Res. 2012;5:3:193-6.

Deshmukh SA, Ismail TSES. Evaluation of psychotropic drugs use pattern among out patients attending psychiatry department at government medical college and hospital, Nagpur: a cross sectional study. Int J Pharm Bio Sci. 2012;3(3):428-36.

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Published

2019-10-22

How to Cite

Bagewadi, H. G., & Huded, C. B. (2019). Efficacy evaluation of antidepressant drugs utilized at tertiary care centre in North Karnataka in psychiatric outpatient department. International Journal of Basic & Clinical Pharmacology, 8(11), 2465–2469. https://doi.org/10.18203/2319-2003.ijbcp20194785

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Original Research Articles