Antidiabetic activity of Manomani chooranam aqueous extract on female wistar albino rats

Authors

  • Sabari Anandh J. V. Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
  • Manimekalai Kumarappan Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
  • Padmavathi Shanmuganathan Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
  • Subha Vinayagam Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
  • Iyyankannu . Department of Sirappu Maruthuvam, Maria Siddha Medical College, Thiruvattaru, Kanyakumari, India
  • Uma Narayanamurthy Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20194131

Keywords:

Diabetes mellitus, Manomani chooranam, Aqueous extract, Streptozotocin

Abstract

Background: The aim of the present study was to evaluate the antidiabetic potential of Manomani chooranam (MMC), an indigenous polyherbal siddha formulation in Streptozotocin (STZ) induced diabetic female Wistar albino rats.

Methods: Aqueous extract of MMC was prepared. Wistar albino rats were divided into six groups (n=6). Group 1 was kept as normal control, Group 2, 3, 4, 5 and 6 were induced diabetes. After induction, the group 2 was kept as diabetes control; Group 3 received the standard drug metformin (100 mg/kg), whereas Groups 4, 5 and 6 were treated with the aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg doses, respectively for the 21 days. Blood sugar was estimated at the end of each week. At the end of the study, rats were sacrificed and the pancreas was analyzed for histopathological changes. Data expressed as mean±standard error of the mean. Statistical analysis was done using one-way ANOVA followed by post hoc Tukey's test. p<0.05 considered statistically significant.

Results: The groups which received aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg showed a significant decrease in the mean blood sugar level when compared to normal level. The groups which received MMC shows significant reduction in blood sugar level in comparison with standard drug metformin 100 mg/kg.

Conclusions: The aqueous extract of MMC was able to decrease the elevated blood sugar levels in dose dependent manner.

Author Biography

Subha Vinayagam, Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India

Veterinary Surgeon, department of pharmacology

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Published

2019-08-28

How to Cite

J. V., S. A., Kumarappan, M., Shanmuganathan, P., Vinayagam, S., ., I., & Narayanamurthy, U. (2019). Antidiabetic activity of Manomani chooranam aqueous extract on female wistar albino rats. International Journal of Basic & Clinical Pharmacology, 8(9), 2153–2157. https://doi.org/10.18203/2319-2003.ijbcp20194131

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Original Research Articles