DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20161535

Innovative first order elimination kinetics working model for easy learning

Navin Budania, Arka Mondal, Vinod Bharadwaj, Vijay Yadav, Priyamvada Sharma

Abstract


Background:  General pharmacology is the backbone of therapeutic pharmacology. In general pharmacology, pharmacokinetics is a very difficult topic for undergraduate medical students. Knowledge of the kinetics and of the effects of drugs is necessary for the correct use of drugs in therapy. As in the body most of the drugs follow first order elimination kinetics, so it is necessary for all students to know about basic concept of first order kinetics. This can be easily understood by using working models. Our present study is a step in that direction. The objective of this study was planned to develop first order elimination kinetics working models to teach pharmacokinetics principle to the under graduate medical students.

Methods: The current study was planned and executed by the department of pharmacology in SHKM government medical college, Mewat, Haryana, India in the first quarter of 2016. This model was developed from household waste materials like thermocol sheets, coke bottles, waste water pipe, colour etc.

Results: As we know learning is better with live experimentation as compare to theoretical learning, so difficult topics such as elimination kinetics will be taught by help of working models.

Conclusions: First order elimination kinetics is easily understood with the help of above working model. More and more working models could be developed for teaching difficult topics.


Keywords


Pharmacokinetics, Working models, First order elimination kinetics

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References


Gabrielsson J, Weiner D. Pharmacokinetic-pharmacodynamic data analysis: concepts and applications, swedish pharmaceutical press. Stockholm; 2010.

Rescigno A, Segre G. Drug and tracer kinetics. Blaisdell, Waltham (Mass); 1966.

Freeman S, Eddy SL, McDonough M, Smith MK, Okorafor N, Jordt H, et al. Active learning increases student performance in science, engineering, and mathematics. Proceedings of the National Academy of Sciences (PNAS).2014;111(23):8410-5.

Narsimhan B, Mallapragada SK, Peppas NA. Release kinetics, data interpretation. Encyclopedia of Controlled Drug Delivery. E Mathiowitz ed., John Wiley and Sons. 1999;921-35.

Ito S, Lee A. Drug excretion into breast milk: Overview. Adv Drug Deliv Rev. 2003;55:617-27.

Stern P, Radovic N, Buljubasic S. Urinary excretion of methylamphetamine in man. Nature. 1965;206:1260-1.

Sharma KK, Sharma HL, Eds., Principles of Pharmacology, 2nd ed. India; 2011.

Levine RR, Walsh CT, Rochelle D. Pharmacology: drug actions and reactions, 7th ed. Florida; 2004.

Bonwell CC, Eison JA. Active learning: creating excitement in the classroom. ASHEERIC higher education report no.1, George Washington University, Washington, DC; 1991.

Felder RD, Stice WJ, Rugarcia A. The future of engineering education: II. Teaching methods that work, chemical engineering education. 2000;34(1):26-39.