A study on clinical profile of patients presenting with adverse drug reaction: a hospital based prospective observational study

Authors

  • Ram Singh Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
  • Jatinder Kumar Mokta Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
  • Kiran Mokta Department of Microbiology, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
  • Surinder Thakur Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
  • Rajesh Bhawani Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
  • Ramesh . Department of Pharmacology, Indira Gandhi Medical College Shimla, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20194128

Keywords:

Adverse drug reaction, Gastrointestinal bleeding, Anticoagulants

Abstract

Background: The aim of the study was to study the clinical profile of patients presenting with adverse drug reaction.

Methods: The study was conducted in the Department of Medicine, IGMC Shimla from 01 July 2015 to 30 June 2016. A total of 129 patients were included in this study. A detailed history was taken followed by examination of patients. The routine investigations were done and special investigations as per need. For analysis patients detail, suspected drugs and the adverse drug reactions caused by them were used.

Results: Bleeding from various sites was the most common event (39.5%), followed by symptomatic hypoglycemia 22.5% of events and symptomatic hyponatremia in 16.3% events. Amongst various drug classes anticoagulants were the most commonly involved drug class followed by oral hypoglycaemic agents, diuretics and antiplatelets. Type A was predominant ADR constituting (97.7%) of total ADRs and only (2.3%) of ADRs were of type B. After causality assessment, majority 86 (66.6%) were probable related and large number 127 (98.3%) of ADRs were serious which recovered after hospitalization.

Conclusions: Our study revealed that ADRs are frequent and are easily recognized in clinical practice and are mostly preventable. Most ADRs are due to the use of drugs with high toxicity for example, warfarin often results in bleeding. It also shows that careful drug monitoring in hospitals  may lead to reduction of many such ADRs, suggesting that some type A, ADRs may be due to inadequate monitoring of therapies and doses. This study will aid the development of interventions to reduce the impact of ADRs in hospital in-patients.

Author Biography

Jatinder Kumar Mokta, Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India

 

 

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Published

2019-08-28

How to Cite

Singh, R., Mokta, J. K., Mokta, K., Thakur, S., Bhawani, R., & ., R. (2019). A study on clinical profile of patients presenting with adverse drug reaction: a hospital based prospective observational study. International Journal of Basic & Clinical Pharmacology, 8(9), 2140–2144. https://doi.org/10.18203/2319-2003.ijbcp20194128

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Original Research Articles