Published: 2019-08-28

Methotrexate induced ventricular arrhythmia as a medication error: a case report

Shailja S. Shah, Sapna Gupta, Jasvin Vala, Supriya D. Malhotra, Pankaj Patel


Methotrexate (MTX) is the most widely used drug in clinical practice for long term treatment of connective tissue disorders. As this drug has narrow therapeutic index, if it goes unmonitored can lead to life threatening complications. Herein we are describing the case of a patient who presented with ventricular arrhythmia, due to failure to execute MTX therapy in the prescribed frequency and took daily dose of MTX which was meant to be taken as a weekly dose pointing to failure of patient education or patient comprehension regarding MTX and finally succumbed due to cardiogenic shock. We concluded this causality as probable/likely category according to WHO-UMC causality categories.



Methotrexate toxicity, Mucositis, Ventricular arrhythmia

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