A comparative study for efficacy and safety of low doses of clonidine for hemodynamic stability in patients undergoing laparoscopic cholecystectomy


  • Ruchi Choudhary Department of Pharmacology, Teerthanker Mahaveer Medical College & Research centre, Moradabad, Uttar Pradesh, India
  • Preeti Singh Department of Pharmacology, Teerthanker Mahaveer Medical College & Research centre, Moradabad, Uttar Pradesh, India
  • Surabhi Gupta Department of Pharmacology, Subharti medical college, Meerut, Uttar Pradesh, India
  • P. P. Khosla Department of Pharmacology, Maharishi Markendeshwar Institute of medical sciences & research (MMIMSR), MMU, Mullana, Ambala, Punjab, India
  • Prithpal S. Matreja Department of Pharmacology, Teerthanker Mahaveer Medical College & Research centre, Moradabad, Uttar Pradesh, India
  • Upmanyu Singh Department of anesthesia, Sri Sai Hospital, Moradabad, Uttar Pradesh, India




Clonidine, Hemodynamic response, Laparoscopic cholecystectomy, Laryngoscopy, Pneumoperitoneum


Background: This randomized prospective double-blind study was designed to evaluate the efficacy and side effects of low doses clonidine for perioperative haemodynamic stability and postoperative recovery.

Methods: Patient’s with ASA grade I–II undergoing laparoscopic cholecystectomy were randomized into three groups of 30 patients each. All patients received either normal saline 10 ml (Group I) or 0.8 µg/kg (Group II) or 1 µg/kg (Group III) over duration of 180 seconds, 10 min prior to laryngoscopy and intubation. Anaesthesia was induced with 1% propofol (2 mg/kg) and maintained with nitrous oxide 60% in oxygen and isoflurane. The parameters assessed at various time intervals were heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and sedation score.

Results: Both doses of clonidine proved to be effective in perioperative haemodynamic stability. Clonidine 0.8 mcg/kg was as effectve and safer to Clonidine 1 mcg/kg for attenuatíon of the hemodynamíc responses to laparoscopy. There were no significant differences in the parameters of recovery between groups.

Conclusions: Significant hemodynamic derangements can occur during laproscopic cholecystectomy at intubation, pneumoperitoneum and extubation. These were effectively attenuated by premedication with 0.8 mcg/kg and 1 mcg/kg of intravenous clonidine. Dose of 1 mcg/kg though found to be effective but produced adverse effects in form of hypotension and bradycardia.


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How to Cite

Choudhary, R., Singh, P., Gupta, S., Khosla, P. P., Matreja, P. S., & Singh, U. (2019). A comparative study for efficacy and safety of low doses of clonidine for hemodynamic stability in patients undergoing laparoscopic cholecystectomy. International Journal of Basic & Clinical Pharmacology, 8(9), 2102–2107. https://doi.org/10.18203/2319-2003.ijbcp20194122



Original Research Articles