Evaluation of opioid sparing effect of dexmedetomidine and pregabalin using acute pain model in male wistar rats

Authors

  • Sudar Codi R. Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Deemed to be University, Puducherry, India
  • Sumina . Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Deemed to be University, Puducherry, India
  • Uma N. Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Deemed to be University, Puducherry, India
  • Manimekalai K. Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Deemed to be University, Puducherry, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20193201

Keywords:

Dexmedetomidine, Hot plate method, Pregabalin, Tail flick method

Abstract

Background: Adjuvant analgesics are added to pain management regimen to reduce opioid consumption and minimise their side effect. Newer ones like dexmedetomidine and pregabalin have not been thoroughly researched. Objectives of the study to study the opioid sparing effect of dexmedetomidine and pregabalin using tail flick and hot plate method in male wistar rats.

Methods: Forty two rats were grouped into seven groups with six in each group. Analgesic activity was tested using tail flick, where in the reaction time to flick its tail on a heated surface was noted. In the hot plate method, the reaction time to withdraw or lick the paws when placed on heated surface was noted.

Results: The reaction time to flick its tail was prolonged with dexmedetomidine and pregabalin when combined with opioids even in sub therapeutic doses.

Conclusion: Adjuncts like dexmedetomidine and pregabalin can be very useful  in mutimodal pain management and also to reduce the opioid consumption.

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Published

2019-07-23

How to Cite

R., S. C., ., S., N., U., & K., M. (2019). Evaluation of opioid sparing effect of dexmedetomidine and pregabalin using acute pain model in male wistar rats. International Journal of Basic & Clinical Pharmacology, 8(8), 1911–1914. https://doi.org/10.18203/2319-2003.ijbcp20193201

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Original Research Articles