Assessment of quality of life in patients on antiepileptic drugs: a hospital based cross sectional study
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20192634Keywords:
Antiepileptics, Cognitive, EpilepsyAbstract
Background: Quality of life (QOL) is a broad, multidimensional concept that usually includes subjective evaluations of both positive and negative aspects of life. Very few studies have been carried out on QOLIE 31 in India and research in this area will identify factors affecting QOL. study was therefore conducted to determine the level of health related QOL of patients of epilepsy in a tertiary care teaching hospital. To evaluate patterns of the use of anti-epileptic drugs (AEDs) and their impact on the Quality of Life (QOL) in patients with epilepsy.
Methods: The study was a hospital based cross sectional study conducted by the Department of Pharmacology in association with the Department of Medicine, Government Medical College, Srinagar. A total number of 134 patients, aged >18 years were studied for a period of one and a half years, January 2015-July 2016. QOLIE‑31 questionnaire was used for collecting data on health‑related QOL.
Results: The mean overall QOLIE-31 score was 53 corresponding to a t-score of 44. Amongst the QOLIE-31 subscales, the highest mean score was the cognitive subscale (73.6) followed by medication effects (55.5) and social functions (52).
Conclusions: It is evident from our study that there are many factors that influence QOL of people with epilepsy. Among them, type of drug therapy plays an important role. Adding clinical counselling and other interventions to address the physical, mental, psychological, social, and emotional aspects of health wellbeing is likely to achieve better health outcomes for epilepsy patients.
References
De Boer HM, Mula M, Sander JW. The global burden and stigma of epilepsy. Epilepsy Behav. 2008;12(4):540-6.
International League Against Epilepsy Quality of life: general considerations. Epilepsia. 2003;44 (Suppl. 6):58-158.
Forsgren I, Beghi E, Ekman M. Cost of epilepsy in Europe. Eur J Neurol. 2005;12(Suppl 1):54-8.
Espie CA, Watkins J, Duncan R, Sterrick M, Mcdonach E, Espie A, et al. Perspectives on epilepsy in people with intellectual disabilities: comparison of family carer, staff carer and clinician score profiles on the Glasgow Epilepsy Outcome Scale (GEOS). Seizure. 2003;12(4):195-202.
Cramer JA. Quality of life and compliance. In M. R. Trimble & W. E. Dodson (Eds.), Epilepsy and quality of life. New York, NY, US: Raven Press; 1994:49-63.
The WHOQOL Group. The World Health Organization Quality of Life Assessment (WHOQOL): development and psychometric properties. Soc Sci Med. 1998;46(12):1569-85.
Centers for Disease Control and Prevention. Measuring Healthy Days: Population assessment of health-related quality of life. Atlanta, Georgia: CDC. 2000. Available at: https://www.cdc.gov/hrqol/pdfs/mhd.pdf. Accessed on Nov 2000.
Nabukenya AM, Matovu JK, Wabwire-Mangen F, Wanyenze RK, Makumbi F. Health-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a cross-sectional study. Health Quality Life Outcomes. 2014;12(1):12-49.
Mahrer-Imhof R, Jaggi S, Bonomo A, Hediger H, Eggenschwiler P, Krämer G, et al. Quality of life in adult patients with epilepsy and their family members. Seizure. 2013 Mar 1;22(2):128-35.
Thomas SV, Koshy S, Nair CS, Sarma SP. Frequent seizures and polytherapy can impair quality of life in persons with epilepsy. Neurol India. 2005 Jan 1;53(1):46-50.
Tedrus GM, Fonseca LC, Carvalho RM. Epilepsy and quality of life: socio-demographic and clinical aspects, and psychiatric co-morbidity. Arquivos de neuro-psiquiatria. 2013 Jun;71(6):385-91.
Mathur S, Sen S, Ramesh L, Kumar SM. Utilization pattern of antiepileptic drugs and their adverse effects, in a teaching hospital. Asian J Pharm Clin Res. 2010 Jan;3(1):55-9.
Anderson M, Egunsola O, Cherrill J, Millward C, Fakis A, Choonara I. A prospective study of adverse drug reactions to antiepileptic drugs in children. BMJ open. 2015 May 1;5(6):e008298.
Ramakrishna P, Barman AK, Mahanta ML, Ramaiah M. Collection, Detection, Assessment, Monitoring and Prevention of Adverse Drug Reactions in the Nephrology Department of Gauhati Medical College and Hospital, Assam, India. Global J Med Res. 2014 Jun 13;5(8):653-57.
Jayalekshmi K, Palanisamy K, Sambathkumar Ramanathan SA. A Study on the Adverse Drug Reactions Induced by Anti-Epileptic Drugs in the Epileptic Patients. J Applied Pharmaceut Sci. 2016;6(05):119-23.
Pimpalkhute SA, Bajait CS, Dakhale GN, Sontakke SD, Jaiswal KM, Kinge P. Assessment of quality of life in epilepsy patients receiving anti-epileptic drugs in a tertiary care teaching hospital. Indian J Pharmacol. 2015;47(5):551-4.
Sawant N, Kinra V. An Indian study on perceptions of patients of epilepsy and their family to stigma and its impact on quality of life. Am J Clin Neurol Neurosurgery. 2015;1(1):1-9.
McLaughlin DP, Pachana NA, Mcfarland K. Stigma, seizure frequency and quality of life: the impact of epilepsy in late adulthood. Seizure. 2008;17(3):281-7.
Nubukpo P, Clément JP, Houinato D, Radji A, Grunitzky EK, Avodé G, et al. Psychosocial issues in people with epilepsy in Togo and Benin (West Africa) II: Quality of life measured using the QOLIE 31 scale. Epilepsy Behav. 2004;5(5):728-34.
Norsa’adah B, Zainab J, Knight A. The quality of life of people with epilepsy at a tertiary referral centre in Malaysia. Health and quality of life outcomes. 2013;11(1):143.
Baker GA, Jacoby A, Buck D, Stalgis C, Monnet D. Quality of life of people with epilepsy: A European study. Epilepsia. 1997;38(3):353-62.
