Metabolic effects of oral vitamin D supplementation as an adjuvant therapy on subjects with type 2 diabetes


  • Sana Tafseer Department of Pharmacology, Al-Falah School of Medical Sciences, Dhouj, Haryana, India
  • Irfan Ahmad Khan Department of Pharmacology, Mayo Institute of Medical Sciences, Barabanki, Lucknow, India
  • Avijit Roy Directorate of Health Services, Port Blair, Andaman And Nikobar, India
  • Pooja Goyal Department of Community Medicine, ESIC Medical College, Faridabad, Haryana, India
  • Virender K. Chhoker Department of Forensic Medicine, Santosh Medical College, Ghaziabad, Uttar Pradesh, India
  • Abhishek Singh Department of Community Medicine, SHKM Government Medical College, Mewat, Haryana, India
  • Priyamvada Sharma Department of Pharmacology, FH Medical College And Hospital, Tundla, Uttar Pradesh, India



Diabetes mellitus, Supplementation, Vitamin D


Background: It is common for patients with type 2 diabetes mellitus (T2DM) to have vitamin D deficiency. Aim of the study is to determine the metabolic effects of oral vitamin D supplementation in a cohort of T2DM subjects.

Methods: Subjects with T2DM were divided into two groups. Group A (Control) included subjects who received the standard treatment (conventional antidiabetic drugs). Group B (Intervention), apart from the standard treatment (conventional antidiabetic drugs), was also supplemented with Vitamin D3. All the patients were followed up at baseline, 6 months, 12 months and 18 months.

Results: Vitamin D deficiency was noted down in all the study subjects. Even after 18 months of supplementation, all subjects remained vitamin D deficient. There was a significant improvement in the circulating levels of 25-hydroxyvitamin D. Improvement in the lipid profile of subjects was observed as evidenced by a decrease in total cholesterol (5.0±0.92 mmol/l) as compared to baseline (5.5±1.6 mmol/l). HOMA-IR changed significantly after 18 months of supplementation from baseline (7.0±1.06 vs 10.8±1.96 nmol/l).

Conclusions: Supplementation to achieve higher levels of vitamin D remains a promising adjuvant therapy for T2DM patients. Additionally, the intervention brought out a favourable change in HDL/LDL ratio among study subjects.


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How to Cite

Tafseer, S., Khan, I. A., Roy, A., Goyal, P., Chhoker, V. K., Singh, A., & Sharma, P. (2019). Metabolic effects of oral vitamin D supplementation as an adjuvant therapy on subjects with type 2 diabetes. International Journal of Basic & Clinical Pharmacology, 8(8), 1866–1869.



Original Research Articles