Antibiotics sensitivity and resistant pattern in tribal region of Chhattisgarh, India: a retrospective observational study
Keywords:Antimicrobial, Baster, Cephalosporins, Imipenem, Resistance, Retrospective, Sensitivity
Background: Antimicrobial resistance (AMR) is the biggest health care problem globally, it is responsible for the high rate of mortality worldwide which was commonly observed in developing countries. We tried to find the incidence of antimicrobial resistance in the tribal region of Chhattisgarh, India.
Methods: It was an institutional based retrospective observational study. Out of 3389 samples from inpatient and outpatient department, a total number of 1676 cultured proven micro-organism were isolated from Jan 2017 to Dec 2018. SPSS v23 was used for descriptive analysis.
Results: More than 75% of the samples collected from the inpatient department in which surgical IPD were significantly higher. The commonest isolated were Staphylococcus aureus followed by Escherichia coli, then Klebsiella species. Amoxycillin-clavulanic acid was resistant to the majority of microorganism followed by 3rd generation cephalosporins then Co-trimoxazole.
Conclusions: Antimicrobial resistance was higher even in the tribal region. The incidence of AMR is increasing at an alarming rate. Microorganism targeted antimicrobial therapy with the use of narrow-spectrum antibiotics and avoidance of broad-spectrum antibiotics will possibly overcome the antimicrobial resistance. There is also a need to strengthen laboratory or microbiology department to produce an accurate report to combat antimicrobial resistance.
World Health Organization. The world health report 1996-Fighting disease, fostering development. Geneva: 1996. Available at: https://www.who.int/whr/1996/en/. Accessed 24 May 2019.
Jarvis WR. Preventing the emergence of multidrug resistant microorganisms through antimicrobial use controls: the complexity of the problem. Infect Control Hosp Epidemiol. 1996;17:490-5.
Shlaes DM, Gerding DN, John JF, Craig WA, Bornstein DL, Duncan RA, et al. Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance guidelines for the prevention of antimicrobial resistance in hospitals. Infect Control Hosp Epidemiol. 1997 Apr;18(4):275-91.
Murthy R. Implementation of strategies to control antimicrobial resistance. Chest. 2001 Feb 1;119(2):405S-11S.
Nordmann P, Naas T, Poirel L. Global spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17(10):1791-8.
Gandra S, Mojica N, Ashok A, Das BR, Laxminarayan R. Trends in antibiotic resistance among bacteria isolated from blood cultures using a large private laboratory network data in India: 2008-2014. Antimicrob Resist Infect Contr. 2015 Dec;4(1):O42.
Epub 2011 Apr 1. Cars O, Hedin A, Heddini A. The global need for effective antibiotics-moving towards concerted action. Drug Resist Updat. 2011 Apr 1;14(2):68-9.
World Health Organization (2018). Antimicrobial resistance. Fact sheet N°194, February 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance. Accessed 24 May 2019.
Centers for disease control and Prevention (2015). National action plan for combating antibiotic-resistant bacteria. Available at: https://www.cdc.gov/drugresistance/pdf/national_action_plan_for_combating_antibotic-resistant_bacteria.pdf. Accessed 24 May 2019.
Atkinson BA, Lorian VI. Antimicrobial agent susceptibility patterns of bacteria in hospitals from 1971 to 1982. J Clin Microbial. 1984 Oct 1;20(4):791-6.
Baldwin JN, RHEINS MS, Sylvester RF, Shaffer TE. Staphylococcal infections in newborn infants: III. Colonization of newborn infants by staphylococcus pyogenes. Am J Dis Child. 1957 Aug 1;94(2):107-16.
Boyce JM. Nosocomial Staphylococcal infection. Am Intern Med J. 1981;95:241-2.
Neihart RE, Fried JS, Hodges GR. Coagulase-positive Staphylococci. South Med J. 1988;81:491-500.
Menezes GA, Harish BN, Sujatha S, Vinothini K, Parija SC. Emergence of vancomycin-intermediate Staphylococcus species in southern India. J Med Microbiol. 2008 Jul 1;57(7):911-2.
Saravanan R, Raveendaran V. Antimicrobial resistance pattern in a tertiary care hospital: An observational study. J Basic Clin Pharma. 2013 Jun;4(3):56-63.
Bhatt P, Tandel K, Shete V, Rathi KR. Burden of extensively drug-resistant and pandrug-resistant Gram-negative bacteria at a tertiary-care centre. New microbes and New infections. 2015 Nov 1;8:166-70.