DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20194111

Drug utility pattern of antiulcer agents used in osteoarthritis patients at tertiary care hospital

Syed Ubaid Razvi, Shrikant B. Lahamate

Abstract


Background: Osteoarthritis is the most common form of joint disease and the leading cause of pain in elderly people. Osteoarthritis (OA) is a progressive and painful chronic disease that mainly affects knee, hand and hip joints.

Aim of study was to evaluate current trend of antiulcer drugs and to assess the group of antiulcer agents use in osteoarthritis patient.

Methods: A prospective observational study was conducted in a tertiary care hospital for period of twelve months in collaboration with department of orthopaedics. Patients data recorded in case report form and analysed to study prescription pattern and related information

 Results: Total of 630 cases were enrolled in this study. Prescribed antiulcer drugs in OA were ranitidine, omeprazole, pantoprazole, rabeprazole, sucralfate and esomeprazole. Most commonly prescribed drug was Ranitidine i.e. 80.79% followed by omeprazole i.e. 8.42% pantoprazole i.e. 3.97% rabeprazole i.e. 3.81%, sucralfate i.e. 2.53% and esomeprazole i.e. 0.48% respectively. In this study, the commonest group prescribed was H2 blockers i.e. 80.79% followed by proton pump inhibitors i.e. 16.68%, and ulcer healing agent i.e. 2.53% respectively.

Conclusions: Most commonly prescribed drug was ranitidine followed by omeprazole, pantoprazole, rabeprazole, sucralfate and esomeprazole respectively. In this study, the commonest group prescribed was H2 blockers followed by proton pump inhibitors, and ulcer healing agent respectively. 


Keywords


Antiulcer drugs, Drug utilization study, Osteoarthritis, Ranitidine

Full Text:

PDF

References


Ahmed M, Ali N, Rahman ZU, Khan MM. A study on prescribing patterns in the management of arthritis in the department of orthopaedics. Der Pharm Lett. 2012;4(1):5–27.

Rosemann T, Wensing M, Joest K, Backenstrass M, Mahler C, Szecsenyi J. Problems and needs for improving primary care of osteoarthritis patients: The views of patients, general practitioners and practice nurses. BMC Musculoskelet Disord. 2006;7:1–9.

Nüesch E, Dieppe P, Reichenbach S, Williams S, Iff S, Jüni P. All cause and disease specific mortality in patients with knee or hip osteoarthritis: Population based cohort study. Bmj. 2011;342(7798):638.

Patel PB, Patel TK. Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials. Eur J Rheumatol [Internet]. 2017;4(1):11–8. Available from: http://www.eurjrheumatol.org/sayilar/209/buyuk/11-18.pdf

Hafez AR, Alenazi AM, Kachanathu SJ, Alroumi AM, Mohamed ES. Knee Osteoarthritis: A Review of Literature. Phys Med Rehabil Int. 2014;1(5):8.

Simon LS, Weaver AL, Graham DY et al. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis. JAMA 1999; 282: 1921-8.

Singh G. Recent considerations in non-steroidal anti-inflammatory drug gastropathy. Am J Med 1998; 105 (1B):31S-38S.

Gurung S, Babu S, Sabu S, Shibu RM, Begum R, Nanjwade BK. A STUDY ON PRESCRIBING PATTERN IN THE MANAGEMENT OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS IN THE. 2016;5(4):1472–93.

Gupta R, Malhotra A, Malhotra P, Gupta R, Med JR, Mar S. Study of prescription pattern of drugs used in the treatment of osteoarthritis in a tertiary care teaching hospital : an observational study. 2018;6(3):985–9.

Jyothi R, Pallavi D, Pundarikaksha HP, Sridharmurthy JN, Girish K. a Study of Prescribing Pattern of Nonsteroidal Anti-Inflammatory Drugs in Orthopedic Opd At a Tertiary Care Hospital. (1):1–4

Mrsm PAI. Prescribing Pattern for Osteoarthritis In A Tertiary Care. 2010;(3):2421–6. 123 | Page

Qoul KZ, Thuheerat IN, Ashor A, Hakuz NM. Prescribing Patterns of Non-Steroidal -673-PRESCRIBING PATTERNS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN OUTPATIENT CLINICS AT ROYAL REHABILITATION CENTER IN KING HUSSEIN MEDICAL CENTER. ZUMJ. 2014;20(5).

Kumar R. “ PRESCRIPTION AUDIT OF ANALGESICS IN ORTHOPAEDICS OPDOF A TERTIARY CARE Assistant Professor , Department of Orthopaedics , Darbhanga Medical College ,. 2018;(4):78–9.