DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20192657

A study of prescription pattern of the pharmacotherapy of patients of hypertension at a tertiary care hospital, Aurangabad,Maharashtra, India

Shruti Chandra, Amol Ubale, Deepak Bhosle, Deepali Jayabhaye, Sukhmeen Kaur

Abstract


Background: The overall prevalence for hypertension in India was estimated to be 29.8%. Patient’s optimal adherence with antihypertensive drug therapy is essential for preventing serious complications with hypertension over the long term. Therefore, the present study was undertaken to evaluate the prescription pattern of the drugs prescribed to hypertensive patients.

Methods: Present study was a prospective cross sectional observational study carried out in the outpatient of department of general medicine of MGM Hospital, a tertiary care teaching hospital, in Aurangabad. Prescriptions of 120 diagnosed hypertensive patients were analysed. Data was recorded as mean±standard deviation.

Results: The mean age of the patients was 57.13±10.94 years with range 18-80 years. 82.5 % (99) of patients were male and 17.5% (21) of patients were female. Mean duration of hypertension was 3.97±2.55. Most of the patients 57 (47.5%) were on Mono therapy significantly higher than dual therapy, triple therapy and poly therapy, 39 (32.5%), 15 (12.5%), 9 (7.5%) respectively. Calcium channel blocker was the frequently used class of drug for monotherapy (20%). Polytherapy was seen in 7.5% patient. Among 120 patients’ only 37 patients were reported ADR. Maximum no of ADRs were reported from patients receiving ACE inhibitor.

Conclusions: This type of studies gives the base line idea of prescription pattern and ADRs of antihypertensive drugs. These help to design policy for rational use of drugs and motivation of physician for rational use of drugs.


Keywords


ADR, Hypertension, Prescription pattern

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References


Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. The Vascular System, 7th, Churchill Livingstone-Elsevier;2012:277-283.

Walker BR, Colledge NR, Ralston SH, Penman ID. Hypertension, Davidson’s Principles and Practice of Medicine. 21st Edition, Churchill Livingstone-Elsevier;2010:606-610.

Singh RB, Suh IL, Singh VP, Chaithiraphan S, Laothavorn P, Sy RG, et al. Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention. J Hum Hypertens. 2000 Oct;14(10):749‐63.

Gupta R, Gupta VP. Hypertension epidemiology in India: Lessons from Jaipur Heart Watch. Curr Sci. 2009;97(3):349‐55.

Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et al. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens. 2014;32(6):1170-7.

James PA, Oparil S, Carter BL, Cushman WC, Himmelfarb CD, Handler J, et al. Evidence-based guideline for the management of high blood pressure in adults. Report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. 2014;311(5):507-20.

Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Himmelfarb CD, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(19):e127-248.

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018 Aug 25;39(33):3021-104.

Chobanian AV, Bakris JL, Black HR, Cushman WC, Green LA. Seventh report of the joint national committee on prevention, detection, evaluation and treatment of high blood pressure. Hypertension. 2003;42(6):1206‐52.

Yusuff KB, Balogun OB. Physicians' prescribing of antihypertensive combinations in a tertiary care setting in southwestern Nigeria. J Pharm Pharm Sci. 2005;8(2):235-42.

Tiwari H, Kumar A, Kulakarni SK. Prescription monitoring of anti-hypertensive drug utilization at the panjab university health centre in India. Singapore Med J. 2004; 45(3):117-20.

Kapoor K, Raina RK, Kapoor S. Drug prescribing pattern in a teaching hospital. Indian J Pharmacol. 1985;17(1):168.

Pradhan SC, Shewade DG, Shashindaran CH, Bapna JS. Drug Utilization studies. National Med J India. 1988;1(4):185-9.

Tasneem S, Fouzia N. Drug utilization study in ischemic heart diseases associated with diabetes and hypertension. Int J Pharm Bio Sci. 2010;1(3):1-4.

Sharma A, Badwal TK, Gupta V, Rathore MS, Chhabra M, Gaur A. Drug Utilization Study on Hypertensive Patients and Assessment of Medication Adherence to Jnc-8 Guidelines in North Indian Tertiary Care Hospital: A Cross-Sectional Study. Adv Res Gastroentero Hepatol. 2018;9(1):555751.

Mohd AH, Mateti UV, Konuru V, Parmar MY, Kunduru BR. A study on prescribing patterns of antihypertensives in geriatric patients. Perspect Clin Res. 2012;3(4):139-42.

Ganachari MS, Wadhwa T, Walli S, Disha AK, Aggarwal A. Trigger tools for monitoring and reporting of adverse drug reactions: A Scientific tool for efficient reporting. Open Access Scientific Rep. 2013;2(4):1-5.

Singh H, Kumar BN, Sinha T, Dulhani N. The incidence and nature of drug-related hospital admission: A 6-month observational study in a tertiary health care hospital. J Pharmacol Pharmacother. 2011;2(1):17-20.