DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20192209

Prescribing pattern of anticancer drugs in the medical oncology department of a tertiary care teaching hospital

Ravindra S. Beedimani, Sameer Uz Zaman, Sharat Chandra Potturi, Srinivas M., K. Santosh Kumar

Abstract


Background: To study drug utilization of anticancer drugs in the oncology inpatient department (IPD) of Kamineni Hospitals, L.B. Nagar, Hyderabad, India.

Methods: One hundred prescription records were screened and analysed as per the study parameters from the oncology IPD of Kamineni Hospitals, Hyderabad. Commonly used anticancer drugs were recorded; furthermore, different types of carcinomas were noted.

Results: Age group of patients was in between 04 and 80 years, 62 were females and 38 were male patients. The most common type of carcinoma was carcinoma of the breast (28%). Cisplatin was the most commonly used anticancer drug (29%). Adjuvant drugs were used in 98% of the patients.

Conclusions: Incidence of cancer is more in females than males. Adjuvant and cytoprotective drugs used may have had a bearing on the relatively lower incidence of adverse effects.


Keywords


Anticancer drug, Carcinoma, Drug utilization, Oncology

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References


Fitzmaurice, C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncology, 2017;3(4):524-48.

Chalkidou K, Marquez P, Dhillon PK, Teerawattananon Y, Anothaisintawee T, Gadelha CA, Sullivan R. Evidence-informed frameworks for cost-effective cancer care and prevention in low, middle, and high-income countries. Lancet Oncol. 2014;15(3):e119-31.

Sivaram S, Majumdar G, Perin D, Nessa A, Broeders M, Lynge E, et al. Population-based cancer screening programmes in low-income and middle-income countries: regional consultation of the International Cancer Screening Network in India. Lancet Oncol. 2018 Feb 1;19(2):e113-22.

Dhillon PK. India State-Level Disease Burden Initiative Cancer Collaborators. The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990-2016. Lancet Oncol. 2018;19(11):E581.

Shewach DS, Kuchta RD. Introduction to cancer chemotherapeutics. Chem. Rev. 2009;109:2859-61.

Nussbaumer S, Bonnabry P, Veuthey JL, Fleury-Souverain S. Analysis of anticancer drugs: a review. Talanta. 2011;85(5):2265-89.

D.E. Thurston, Chemistry and Pharmacology of Anticancer Drugs, CRC Press. Taylor and Francis Group, Boca Raton, 2007.

Shalini S, Ravichandran V, Mohanty BK, Dhanaraj SK, Sraswathi R. Drug utilisation studies - An overview. Int J Pharm Sci Nanotechnol. 2010;3(1):803-10.

WHO Regional Publication - Studies in Drug utilisation. European Series Number 8. Copenhagen: Who Regional Publication; 1979.

Hawkey CJ, Hodgson S, Norman A, Daneshmend TK, Garner ST. Effect of reactive pharmacy intervention on quality of hospital prescribing. BMJ. 1990;300(6730):986-90.

Sjoqvist F, Birkett D. Drug utilisation. WHO Booklet. Chapter 10. Sweden, Australia: WHO; 2003.

Kulkarni MD, Hussaini SA, Padwal SL, Khandelwal PN, Doifode SM, More PP. Drug utilization review of anticancer drugs in cancer outpatient department of the Government Medical College, Aurangabad. Int J Basic Clin Pharmacol 2014;3:879-83.