DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20192194

Evaluation of wound healing activity of Hibiscus rosa sinensis linn in albino rats

Monil Yogesh Neena Gala, Swanand S. Pathak

Abstract


Background: From debridement to the appearance of healthy granulation tissue is the maximum time during which the patient suffers more economically and psychologically. Due to high cost expenditure in hospitalisation, dressing material cost and loss of daily earnings during this period which puts a psychological pressure over patient and family especially in India where majority of the population is still below poverty line. Also access to quick treatment is yet not possible to majority of population living in rural with no access to basic healthcare.

Methods: It was an experimental study wherein Wistar rat models were used to check for the wound healing property of Hibiscus Rosa Sinensis (HRS) compared with one of the common standard drugs of treatment for available today, betadine. To observe the wound healing property of the HRS flower extract, the experiment was divided into 2 parts i.e. excision wound model and incision wound model. The groups were treated with respective medication along with a control group of rats.

Results: At the end of the experiment, it was observed that HRS flower extract increased the wound breaking strength as compared to control but not as effectively as compared to the betadine ointment.

Conclusions: HRS flower extract helps in early epithelization and helps in decreasing the wound size. Betadine is associated with adverse events like life threatening allergic reactions, water retention, etc.

Keywords


Animal, Betadine, Hibiscus, Skin, Flower, Wound healing, Wistar

Full Text:

PDF

References


Forrest RD. Early history of wound treatment. J R Soc Med. 1982;75(3):198-205.

Shield HealthCare. How wounds heal: the 4 main phases of wound healing, 2015. Available at: http://www.shieldhealthcare.com/community/wound/2015/12/18/how-wounds-heal-the-4-main-phases-of-wound-healing/. Accessed 21 September 2018.

Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008;97(8):2892-923.

Gupta N, Gupta SK, Shukla VK, Singh SP. An Indian community-based epidemiological study of wounds. J Wound Care. 2004;13(8):323-5.

Daunton C, Kothari S, Smith L, Steele D. A history of materials and practices for wound management. Wound Pract Res. 2012;20:174-86.

Shivananda NB, Raju SS, Orette FA, Rao CAV. Effects of Hibiscus rosa sinensis L (Malvaceae) on wound healing activity: a preclinical study in a sprague dawley rat. Int J Low Extrem Wounds. 2007;6(2):76-81.

Bhaskar A, Nithya V. Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats. Indian J Pharmacol. 2012;44(6):694-8.

Meena AK, Jain A, Pandey K, Singh RK. Acute toxicity and genotoxic activity of Hibiscus rosa-sinensis flower extract. Am J Phytomed Clin Therapeutics. 2014;2(4):524-9.

Raduan SZ, Abdul Aziz MW, Roslida AH, Zakaria ZA, Zuraini A, Hakim MN. Anti-inflammatory effects of Hibiscus rosa-sinensis L. and Hibiscus rosa-sinensis var. alba ethanol extracts. Int J Pharm Pharmaceut Sci. 2013;5(4):754-62.

Davis SV, Shenoi SD, Prabhu S, Shirwaiker A, Balachandran C. Clinical evaluation of patients patch tested with plant series: a prospective study. Indian J Dermatol. 2011;56(4):383-8.

Injectable Anesthesia. Research at Penn State. Available at: https://www.research.psu.edu/arp/anesthesia/injectable-anesthesia.html. Accessed 27 August 2018.

Morton JJ, Malone MH. Evaluation of vulneray activity by an open wound procedure in rats. Arch Int Pharmacodyn Ther. 1972;196(1):117-26.

Bhaskar A, Nithya V. Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats. Ind J Pharmacol. 2012;44(6):694–8.

Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. Ann Surg. 1968;167(3):324-8.

Lodhi S, Jain AP, Rai G, Yadav AK. Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats. J Ayurveda Integr Med. 2016;7(1):14-22.

Shen HM, Chen C, Jiang JY, Zheng YL, Cai WF, Wang B, et al. The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds. J Ethnopharmacol. 2017;198:291-301.

Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon J-K, Wa CTC, Villa MA. Povidone iodine in wound healing: a review of current concepts and practices. Int J Surg. 2017;44:260-8.

Burks RI. Povidone-iodine solution in wound treatment. Phys Ther. 1998;78(2):212-8.

Durani P, Leaper D. Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation. Int Wound J. 2008;5(3):376-87.

Fleischer W, Reimer K. Povidone-iodine in antisepsis-state of the art. Dermatol. 1997;195(2):3-9.

McDowell S. Are we using too much Betadine? RN. 1991;54(7):43-5.