Titanium dioxide nanoparticles decreases activity of rat brain when administered prenatally

Nikita Saraswat; Pranay Wal; Ankita Wal; Shikha Bajpai; Rituparna Palit

doi:10.18203/2319-2003.ijbcp20161510

Authors

Nikita Saraswat Department Pharmacy Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India
Pranay Wal Department Pharmacy Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India
Ankita Wal Department Pharmacy Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India
Shikha Bajpai Department Pharmacy Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India
Rituparna Palit Shri Ram Murti Smarak College of Engineering and Technology, Bareilly, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20161510

Keywords:

Conditioned avoidance response, Brain damage, Neurotoxicity, Nanoparticles, Neurogenesis

Abstract

Background: Titanium dioxide nanoparticles are widely used in the sunscreens, toothpastes, and cosmetic products that the human use daily. Previous reports have proved that the impact of nanomaterials on brain activity is not negligible, especially for the people working in nanomaterials manufacturing factories. We are using titanium dioxide in our daily life in cosmetics, food industry and many other pharmaceutical products. So to keep a check on the threat what these chemicals may cause, we conducted a research to study effect of titanium dioxide nanoparticles on rat brain. This research gave us an insight of the possible threats it can cause to brain.

Methods: The effects of titanium dioxide nanoparticles on brain activity were reported. Our studies showed that titanium dioxide nanoparticles have a differential tendency towards neurons. To insight the possible effect on titanium dioxide nanoparticles on neurobehaviour we conducted a conditioned avoidance response study using shuttle box analysis. In the study we administered the drug titanium dioxide nanoparticles prenatally and observed its effects by neurobehaviour studies in progenies of wistar rat.

Results: In the results we observed that titanium dioxide nanoparticles have caused a decreased learning and memory behaviours as compared to control groups.

Conclusions: We studied the neurobehaviour of progenies, when the drug was administered to rat brain prenatally. The results showed that the titanium dioxide nanoparticles particles have decreased the brain activity of the rat brain by showing decreased brain activity in progenies also.

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