Analysis of prescribing pattern of antihypertensive drugs during pregnancy and neonatal outcome in a tertiary care centre

Authors

  • Soundarya Yamakanamardi Department of Pharmacology,M. S. Ramaiah Medical College and Hospital, Bengaluru, India, 560054
  • Anuradha HV Department of Pharmacology,M. S. Ramaiah Medical College and Hospital, Bengaluru, India, 560054
  • Sujani BK Department of Obstetrics and Gynaecology, M. S. Ramaiah Medical College and Hospital, Bengaluru, India, 560054
  • Shivamurthy MC Department of Pharmacology,M. S. Ramaiah Medical College and Hospital, Bengaluru, India, 560054

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20161507

Keywords:

Antihypertensive drugs, Pregnancy, Neonatal outcome, Retrospective study

Abstract

Background: Hypertensive disorders are the most common medical complications of pregnancy with an incidence of 2-8%. Maternal hypertension, even of the mild to moderate category, can lead to adverse perinatal outcomes like low birth weight, prematurity, stillbirth and intrauterine growth retardation. Though hypertension occurs up to 8% of pregnancies, yet information on the safety of antihypertensive medication use during pregnancy is limited. The objective of this study was to analyse the prescription pattern of antihypertensive drugs in pregnant woman and also to assess the neonatal outcome in pregnant woman on antihypertensive drugs.

Methods: The retrospective study includes analysis of all the prescriptions from case records of hypertensive pregnant women till the delivery for one year.

Results: Total number of 122 hypertensive pregnant patients was included in the study. Mean age of the patients was 25.8 years. 51.6% were primigravida. Most of them were diagnosed after 28±2 weeks of pregnancy. 54% were on monotherapy. Most commonly used drug was alpha methyl dopa followed by nifedipine. Out of 86.9% (n=106) live birth delivered; 29.2% were of low birth weight.

Conclusions: All the prescriptions were prescribed rationally. Most of the prescriptions contain monotherapy with alpha methyl dopa which is considered to be safest antihypertensives in pregnancy.

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Published

2016-12-30

How to Cite

Yamakanamardi, S., HV, A., BK, S., & MC, S. (2016). Analysis of prescribing pattern of antihypertensive drugs during pregnancy and neonatal outcome in a tertiary care centre. International Journal of Basic & Clinical Pharmacology, 5(3), 718–721. https://doi.org/10.18203/2319-2003.ijbcp20161507

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Original Research Articles