A prospective study, to determine adverse effects of anti-retroviral agents in rural tertiary care teaching hospital


  • Swapnil Chudaman Jaykare Department of Pharmacology, RCSM Medical College, Kolhapur, Maharashtra 416002, India
  • Jyoti Ramchandra Patil Department of Pharmacology, BVDU Medical College, Sangli, Maharashtra 416414, India
  • Vijay Motiram Motghare Department of Pharmacology, GMC Nagpur, Maharashtra 440009, India
  • Sudhir Laxmanrao Padwal Department of Pharmacology SRTR GMC, Ambajogai, Dist: Beed, Maharashtra 415417, India
  • Vinod Shivajirao Deshmukh Department of Pharmacology GMC Latur, Maharashtra 413512, India
  • Harshal Nutanrao Pise Department of Pharmacology SRTR GMC, Ambajogai, Dist: Beed, Maharashtra 415417, India




ADRs, AIDS, Antiretroviral therapy, Causality, Pharmacovigilance, Preventability, Severity


Background: Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). Objective of this study was to evaluate the adverse drug reaction profile of anti-retroviral drugs in HIV patients in terms of causality, severity and preventability.

Methods: Patients newly started on ART were followed prospectively for a period of initial six months and were interviewed in person during their routine follow-up or visit following development of any ADRs. ADRs were screened clinically and investigated accordingly for causality, severity and preventability.

Results: Out of 59 cases, zidovudine+lamivudine+nevirapine (ZLN) was the most commonly used ART regimen. A total 122 ADRs involving various systems were observed in these patients; majority being related to gastrointestinal system (54.10%). Most of these ADRs were observed in the ZLN regimen followed by the stavudine+lamivudine+nevirapine (SLN) regimen. On causality assessment in ZLN regimen, 74.58% of ADRs were possible, while 25.42% were probable. Severity assessment showed that most of the ADR were mild whereas on preventability assessment it was observed that most of the ADRs were not-preventable.

Conclusions: Antiretroviral drugs are not solely responsible for the ADRs due to these medications; various co-morbid and predisposing conditions share the responsibility. An efficient pharmacovigilance is imperative by means of improving ADR reporting and monitoring, in order to improve compliance and acceptability of ART.


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How to Cite

Jaykare, S. C., Patil, J. R., Motghare, V. M., Padwal, S. L., Deshmukh, V. S., & Pise, H. N. (2016). A prospective study, to determine adverse effects of anti-retroviral agents in rural tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology, 5(3), 713–717. https://doi.org/10.18203/2319-2003.ijbcp20161506



Original Research Articles