Antidiabetic activity of Coriandrum sativum in streptozotocin induced diabetic rats

Sayan Das; Sanjeevani Chaware; Nimish Narkar; Abhijeet V. Tilak; Siddhi Raveendran; Pratik Rane

doi:10.18203/2319-2003.ijbcp20191577

Authors

Sayan Das Department of Pharmacology, D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India
Sanjeevani Chaware Department of Pharmacology, D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India
Nimish Narkar Department of Pharmacology, D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India
Abhijeet V. Tilak Department of Pharmacology, D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India
Siddhi Raveendran Department of Pharmacology, D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India
Pratik Rane Department of Pharmacology, D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20191577

Keywords:

BSL, Coriandrum sativum, Diabetes, HbA1C, Metformin, T2DM

Abstract

Background: Diabetes mellitus (DM) can be defined as chronic hyperglycemia due to lack in insulin secretion and/or action. This study was designed to compare the antidiabetic activity of Coriandrum sativum L. with the standard antidiabetic drug, Metformin in Streptozotocin induced diabetic rats.

Methods: Streptozotocin (STZ) was used to induce diabetes in the rats. Standard drug was metformin and test drug were Coriandrum sativum seed extract. 4 groups of 8 rats each were taken (normal control, diabetic control, streptozotocin + Coriandrum sativum and streptozotocin + metformin). Blood Sugar Levels (BSL) and HbA_1C levels were estimated on day 0, 14 and 28 and day 28 respectively.

Results: Streptozotocin administration resulted in significant rise in BSL. This rise was reduced with the administration of CS seed extract, but the reduction was more with chronic administration. It also reduced the HbA_1C levels but couldn’t attain total normoglycemia. However, the reduction of BSL was superior with Metformin compared to the test drug.

Conclusions: Oral administration of Coriandrum sativum seed extract at a dose of 40 mg/kg has shown antihyperglycemic activity in streptozotocin induced diabetic rats. Thus, Coriandrum sativum may have considerable therapeutic benefit as an antidiabetic agent and can be suggested as a potential dietary add on.

Metrics

Metrics Loading ...

References

Kahn CR, Weir GC, King GL, Moses AC, Smith RJ, Jacobson AM, editors. Joslin’s Diabetes Mellitus 14th ed. Boston: Joslin Diabetes Center; 2005.

Ramachandran A. Socio-economic burden of diabetes in India. J Assoc Physicians India. 2007;55(L):9.

Cho NH, Whiting D, Forouhi N, Guariguata L, Li R,Narayan V. IDF Diabetes Atlas [e-book]. 7th ed. Brussels(Bel): International Diabetes Federation; 2015. Available at: http://www.idf.org/diabetesatlas. Accessed 29 January 2017.

King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diab Care. 1998;21(9):1414-31.

Das S, Tilak AV, Narkar N, Dange SV, Rane BT, Shende SS. Prescription preference of antidiabetic drugs among clinicians. Pharma Innovation J. 2019;8(3):59-63.

WHO expert committee on diabetes mellitus -Technical report series 646. 2nd report, World Health Organization, Geneva, 1980:1-80. Available at: https://apps.who.int/iris/handle/10665/41399.

Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diab Care. 2003:26:1277-94.

Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and neutraceuticals: a review. Phytother Res. 2013;27:1439-56.

Aissaoui A, Zizi S, Israili ZH, Lyoussi B. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol. 2011;137(1):652-61.

Sreelatha S, Inbavalli R. Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats. J Food Sci. 2012;77:119-23.

Ghosh MN. Fundamentals of Experimental Pharmacology. 6th ed. Kolkata: Hilton & Company; 2015:173.

Akbarzadeh A, Norouzian D, Mehrabi MR, Jamshidi S, Farhangi A, Verdi AA, et al. Induction of diabetes By Streptozotocin in Rats. Indian J Clin Biochem. 2007;22(2):60-4.

Lorenzi GM, LaRue SM, Collins SE. Effects of a patient education support program on pramlitinide adherence. Clin Diab. 2011;29(1):17-24.

Bailey C, Day C. Metformin: its botanical background. Practical Diab Int. 2004;21(3):115-7.

Wadkar KA, Magdum CS, PAtil SS, Naikwade NS. Antidiabetic potential and Indian medicinal plants. J Herbal Med Toxicol. 2008;2(1):45-50.

Gray AM, Flatt PR. Insulin-releasing and insulin like activity of the traditional anti-diabetic plant Coriandrum sativum (Coriander). Br J Nutr. 1999;81(3):203-209.

Eidi M, Eidi A, Saedi A, et al. Effect of coriander seed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induced diabetic rats. Phytoter Res. 2009;23(3):404-6.

Naquvi KJ, Ali M, Ahamad J. Antidiabetic activity of aqueous extract of Coriandrum sativum fruits in streptozotocin induced rats. Int J Pharma Pharmaceut Sci. 2012;4(1):239-241.

Brindis F, Gonzalez-Andrade M, Gonzalez-Trujano ME, Estrada-Soto S, Villalobos-Molina R. Postprandial glycaemia and inhibition of α-glucosidase activity by aqueous extract from Coriandrum sativum. Nat Prod Res. 2014;28(22):2021-5.

Jelodar G, Mohsen M, S Sirus. Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. Afr J Trad. 2007;4(3):299-305.

Rajeshwari U, Iyer S, Bondada A.Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities. Spatula DD. 2011;1(1):9-16.

Waheed A, Miana GA, Ahmad SI, Khan AM. Clinical Investigation of hypoglycemic effect of Coriandrum sativum in Type 2 (NIDDM) diabetic patients. Pakistan J Pharmacol. 2006:23(1):7-11.

Gallagher AM, Flatt PR, Duffy G, Abdel-Wahab YH. The effects of traditional antidiabetic plants on in vitro glucose diffusion. Nutr Res. 2003 Mar 1;23(3):413-24.