Pharmacological role of atorvastatin in myocardium and smooth muscle progenitor cells

Suresh Kanna, Jai Prabu, Vignesh Marimuthu, Vijaya Anand


Atorvastatin is a synthetic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor with a great potency in the reduction of lipids and it has been well documented in both primary and secondary prevention studies. It exhibits pleiotropic properties in both in-vitro and in vivo conditions. Conversely, atorvastatin remain under-utilized in several situations. The main objective of this review is to focuses the pharmacological benefits, pleiotropic properties of the atorvastatin related to smooth muscle proliferation and myocardium.


Atorvastatin, Smooth muscle cells, Angiotensin, Myocardium

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