Antimicrobial activity of Allium cepa and Cinnamomum zeylanicum against common bacteria causing urinary tract infections: in vitro study


  • Mayank Ravindra Dhore Department of Pharmacology, JNMC, DMIMS, Sawangi Meghe, Wardha, Maharashtra, India
  • Asha R. Jha Department of Pharmacology, JNMC, DMIMS, Sawangi Meghe, Wardha, Maharashtra, India



Allium cepa, antimicrobial activity, Cinnamomum zeylanicum, plant extract, urinary tract infection


Background: This study was undertaken to investigate and compare the antimicrobial effect of Onion bulbs (Allium cepa) and cinnamon bark (Cinnamomum zeylanicum) against some common bacteria causing Urinary tract infection.

Methods: Antimicrobial activity of the plant extract in different concentrations was observed. Commonly isolated bacteria from the urine samples of suspected and untreated patients which were found to be E. coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.

Results: The comparison between zones of inhibition showed a statistically significant data of both Allium cpea and Cinnamomum zeylanicum. The antimicrobial activity of cinnamon extract showed the maximum effect against Klebsiella pneumoniae, zone of inhibition 25.50 mm±3.72 with 2±l of extract and E. coli with zone of inhibition 11.72mm±1.86. The onion (Allium cepa) extract exhibited some antimicrobial effect, it was most effective against E. coli, though the effect was minimal.

Conclusions: From the current study we conclude that the extract of onion and cinnamon bark are promising but were not as effective as the conventional antibiotics such as ciprofloxacin and nitrofurantoin but can be a good alternative in selected group of patient.


Kaur N, Sharma S, Malhotra S, Madan P, Hans C. Urinary Tract Infection: Aetiology and Antimicrobial Resistance Pattern in Infants From A Tertiary Care Hospital in Northern India. J Clin Diagn Res. 2014 Oct;8(10):DC01-3.

Fenwick EA, Briggs AH, Hawke CI. Management of urinary tract infection in general practice: a cost-effectiveness analysis. Br J Gen Pract. 2000 Aug;50(457):635-9.

Han X, Parker TL. Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. Phytother Res. 2017 Jul;31(7):1034-8.

Bassolé IHN, Juliani HR, Bassolé IHN, Juliani HR. Essential Oils in Combination and Their Antimicrobial Properties. Molecules. 2012 Apr 2;17(4):3989-4006.

Kaskatepe B, Kiymaci ME, Simsek D, Erol HB, Erdem1 SA. Comparison of the Contents and Antimicrobial Activities of Commercial and Natural Cinnamon Oils. Ind J Phar Urina Tra Infect Scien. 2016 Jul 20;78(4):541-6.

Gupta C, Garg AP, Uniyal RC, Kumari A. Comparative analysis of the antimicrobial activity of cinnamon oil and cinnamon extract on some food-borne microbes. AJMR. 2008 Sep 30;2(9):247-51.

Santas J, Almajano MP, Carbó R. Antimicrobial and antioxidant activity of crude onion (Allium cepa, L.) extracts. Int J Food Science Technol. 2010 Feb 1;45(2):403-9.

Chang ST, Chen PF, Chang SC. Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. J Ethnopharmacol. 2001 Sep 1;77(1):123-7.

Dhara L, Tripathi A. Antimicrobial activity of eugenol and cinnamaldehyde against extended spectrum beta lactamase producing enterobacteriaceae by in vitro and molecular docking analysis. Eur J Integra Med. 2013 Dec 1;5(6):527-36.

Packia Lekshmi N, Viveka S, Jeeva S, Raja Brindha J. Efficacy of crude extracts of Allium sativum and Allium cepa against human pathogens. Pelagia Research Library Advances in Applied Science Research. 2015:6(1):72-8.

Woźnicka E, Kuźniar A, Nowak D, Nykiel E, Kopacz M, Gruszecka J, et al. Comparative study on the antibacterial activity of some flavonoids and their sulfonic derivatives. Acta Pol Pharm. 2013 Jun;70(3):567-71.

Djara MJ. Performance measurement of district level hospitals in low income countries: participatory development of an instrument to assess inputs, processes, and outputs for evidence-based management and quality improvement (Doctoral dissertation, Boston University).

Kaskatepe B, Kiymaci ME, Suzuk S, Erdem SA, Cesur S, Yildiz S. Antibacterial effects of cinnamon oil against carbapenem resistant nosocomial Acinetobacter baumannii and Pseudomonas aeruginosa isolates. Industrial Crops and Products. 2016 Mar 1;81:191-4.

Azu NC, Onyeagba RA. Antimicrobial Properties Of Extracts Of Allium cepa (Onions) And Zingiber officinale (Ginger) On Escherichia coli, Salmonella typhi And Bacillus subtilis. The Internet Journal of Tropical Medicine [Internet]. 2006 Dec 31 [cited 2018 Oct 14];3(2).

Jaisinghani RN. Antibacterial properties of quercetin. Microbiology Research [Internet]. 2017 May 2;8(1). Accessed 15 October 2018.




How to Cite

Dhore, M. R., & Jha, A. R. (2019). Antimicrobial activity of Allium cepa and Cinnamomum zeylanicum against common bacteria causing urinary tract infections: in vitro study. International Journal of Basic & Clinical Pharmacology, 8(6), 1185–1191.



Original Research Articles