A retrospective study on prevalence of hyperuricemia in patients with hypertension and type 2 diabetes mellitus (T2DM) from a teaching hospital of west Uttar Pradesh, India
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20190135Keywords:
Hyperuricemia, Hypertension, Prevalence, Type 2 diabetes mellitusAbstract
Background: Hyperuricemia have been associated with an increased risk for not only type 2 diabetes mellitus (T2DM) and hypertension but also for metabolic syndrome, hyperinsulinemia, gout and many cardiovascular diseases. The objective of the present study was to determine the prevalence of hyperuricemia in patients with hypertension and / or type 2 diabetes mellitus patients from a teaching hospitals of West Uttar Pradesh.
Methods: A retrospective study was carried out in the department of pharmacology, Teerthanker Mahaveer Medical College and Research centre, Moradabad, West Uttar Pradesh over a period of six months.
Results: A total of 524 case records with high blood pressure and / or type 2 diabetes mellitus were examined during the study period. The mean age of subjects reported was 45 years. A 35.3 % (185/524) were found to have elevated serum uric acid level. The prevalence of hyperuricemia was found increased with an increased duration of disease among hypertensive, diabetic patients.
Conclusions: A high prevalence of hyperuricemia was observed among patients with hypertension, type 2 diabetes mellitus and among the patients with both co-morbidities in our studies.
Metrics
References
Hamburger M, Baraf HS, Adamson TC, Basile J, Bass L, Cole B, Doghramji PP, Guadagnoli GA, Hamburger F, Harford R, Lieberman III JA. 2011 recommendations for the diagnosis and management of gout and hyperuricemia. Postgrad Med. 2011 Nov 2;123(sup1):3-6.
Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogi T, et al 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res. 2012 Oct 1;64(10):1431-46.
Richette P, Bardin T. Gout. Lancet. 2010;375(9711):318-28.
Juraschek SP, Kovell LC, Miller ER, Gelber AC. Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010. Semin Arthritis Rheum. 2013;42(6):55161.
Clarson LE, Hider SL, Belcher J, Heneghan C, Roddy E, Mallen CD. Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink. Ann Rheumatic Dis. 2015 Apr 1;74(4):642-7.
Choi HK, Mount DB, Reginato AM. Pathogenesis of gout. Ann Internal Med. 2005 Oct 4;143(7):499-516.
Billa G, Dargad R, Mehta A. Prevalence of Hyperuricemia in Indian Subjects attending Hyperuricemia Screening Programs-A Retrospective Study. J Assoc Physicians India. 2018 Apr;66:43.
Remedios C, Shah M, Bhasker AG, Lakdawala M. Hyperuricemia: a reality in the Indian obese. Obesity Surgery. 2012 Jun 1;22(6):945-8.
Yamanaka H. Japanese guideline for the management of hyperuricemia and gout. Nucleosides Nucleotides Nucleic Acids. 2011 Dec 1;30(12):1018-29.
Cameron MA, Maalouf NM, Adams-Huet B, Moe OW, Sakhaee K. Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis. J Am Soc Nephrol. 2006 May 1;17(5):1422-8.
King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998 Sep 1;21(9):1414-31.
Ogbera AO, Azenabor AO. Hyperuricaemia and the metabolic syndrome in type 2 DM. Diabetol Metabolic Syndrome. 2010 Dec;2(1):24.
Tuomilehto J, Zimmet P, Wolf E, Taylor R, Ram P, King H. Plasma uric acid level and its association with diabetes mellitus and some biologic parameters in a biracial population of Fiji. Am J Epidemiol. 1988 Feb 1;127(2):321-36.
Mundhe SA, Mhasde DR. The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus. Int J Adv Med. 2016;3:241-9.
Remedios C, Shah M, Bhasker AG, Lakdawala M. Hyperuricemia: a reality in the Indian obese. Obesity Surg. 2012 Jun 1;22(6):945-8.
Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Internal Med. 1999 Jul 6;131(1):7-13.
Billa G, Dargad R, Mehta A. Prevalence of Hyperuricemia in Indian Subjects attending Hyperuricemia Screening Programs-A Retrospective Study. J Assoc Physicians India. 2018 Apr;66:43.