DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20190134

A prospective study on the prescription pattern of anti-cancer drugs and adverse drug reaction in a tertiary care hospital

Harshendra Guduru, Santosh Kumar R. Jeevanagi, Shantiling Nigudgi, Smita V. Bhandare

Abstract


Background: Cancers is a group of disease involving abnormal cell multiplication with the ability to spread to other parts of the body. Common side effects seen with chemotherapy are fatigue, hair loss, easy bruising and bleeding, infection, anemia, nausea and vomiting, appetite changes, constipation etc. The need of this study is to evaluate the prescribing pattern and the adverse drug reaction associated with chemotherapeutic drugs. The study is aimed to analyze the prescribing pattern of anticancer drugs in medical oncology department of a tertiary care hospital, Karnataka.

Methods: An observational study was conducted on 30 patients of either sex admitted for chemotherapy for a period of 6 months in at HCG Cancer Institute, Gulbarga and Basaveshwar Teaching and General Hospital (BTGH), Gulbarga. The data collected is analysed statistically using descriptive statistics and presented as counts and percentages. Results are depicted in the form of tables.

Results: A total of 30 prescriptions were collected with 10 (33.3%) male and 20 (66.6%) female. the maximum number of cases were noted in the age group of 46years to 55 years (10) and least in age group of 15-25 years having a single patient. In our study we found that more number of patients are breast cancer (12 patients) followed by cervical cancer and ovarian cancer (3 patients) and least are Ewing’s sarcoma and Non-Hodgkin’s lymphoma (1 patient). Most commonly prescribed anti-cancer drug is carboplatin and paclitaxel i.e. for 12 patients out of 30 patients, followed by cyclophosphamide for 10 patients and less commonly prescribed drug being dactinomycin and pemitrexate. Adverse drug reactions seen in maximum patients is hair loss among 20 pts followed by peripheral neuropathy (17) and taste change (16) and the less commonly noted side effects being chest pain and ototoxicity.

Conclusions: The study concluded that the drugs which were used in the treatment of various neoplastic conditions are in adherence and in accordance with the standard treatment guidelines and most of them were prescribed with generic name which leads to reduce in cost of treatment.


Keywords


Breast cancer, Chemotherapy, Mutation, Neoplastic disease

Full Text:

PDF

References


Park K. Park’s Textbook of Preventive and Social Medicine. 23rd edition. Jabalpur: Banarasidas Bhanot; 2015:388.

World Health Organization. Fact sheet: Cancer Fact sheet, February 2018. Available at: http://www.who.int/en/news-room/fact-sheets/detail/cancer. Accessed 21 March 2018.

World Health Organization. Fact sheet: World Cancer Report 2014. Available at: http://www.searo.who.int/publications/bookstore/documents/9283204298/en/. Accessed 21 March 2018.

Kanwal R, Gupta S. Epigenetic modifications in cancer. Clin Genet. 2012 Apr;81(4):303-11.

Kushi LH, Doyle C, McCullough M, Rock CL, Demark-Wahnefried W, Bandera EV, et al. American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2012 Jan-Feb;62(1):30-67.

World Health Organization. Fact sheet: World Cancer Report 2014. Available at: http://www.searo.who.int/publications/bookstore/documents/9283204298/en/ Accessed 21 March 2018.

National Cancer Institute. Fact sheet: targeted cancer therapies, 2012. Available at: http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted#q1. Accessed 9 June 2012.

Murthy NS, Rajaram D, Gautham MS, Shivaraj NS, Nandakumar BS, Pruthvish S. Risk of cancer development in India. Asian Pac J Cancer Prev. 2011 Jan 1;12:387-91.

Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M, Comparative risk assessment collaborating group (Cancers. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet. 2005 Nov 19;366(9499):1784-93.

White MC, Holman DM, Boehm JE, Peipins LA, Grossman M, Henley SJ. Age and cancer risk: a potentially modifiable relationship. Am J Preventive Med. 2014 Mar 1;46(3):S7-15.

Lunde PK, Baksaas I. Epidemiology of drug utilizationbasic concepts and methodology. Acta Med Scand Suppl. 1988;721:7-11.

WHO Expert Committee on the selection and use of essential medicines. 2005. Accessible at: https://www.who.int/?ReturnUrl=http:%2F%2Fwww.who.int%2Fmedicines%2Fpublications%2Fessentialmeds_committeereports%2Fen%2F.

Jire AS, Bajait CS, Mahobia VK, Motghare VM. Study of prescription pattern and adverse drug reactions in patients with cervical cancer in tertiary care teaching institute. Int J Basic Clin Pharmacol. 2016;5(4):1594-7.

Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998 Apr 15;279(15):1200-5.

Yeager CE, Oslen EA. Treatment of chemotherapy induced alopecia. Dermatol Ther. 2011 Jul-Aug;24(4):432-42.