Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats


  • Shiva Murthy N. Department of Pharmacology, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India
  • Srinivas V. Department of Pharmacology, Koppal Institute of Medical Sciences, Koppal, Karnataka, India
  • Shanthi M. Department of Pathology, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka, India



Anti-inflammatory, Diclofenac, Nimesulide, NSAIDs, Thiazolidine-4-ones, Ulcerogenicity


Background: NSAIDS are associated with side effects and research should continue for developing safer drugs. This study aims to evaluate newer thiazolidine-4-ones for their anti-inflammatory and ulcerogenic activities in wister rats.

Methods: Five groups of wister rats, 6 in each were used.  Anti-inflammatory and ulcerogenic activities of diclofenac (30mg/kg), nimesulide (50mg/kg), thia-1 (50mg/kg) and thia-2 (50mg/kg) are compared with control group (4% Gum Acacia). Carrageenin-induced paw edema, formaline induced acute peritonitis and cotton pellet-induced granulomatous tissue formation models were used for evaluating anti-inflammatory activity. After removing cotton pellets with granuloma on 8th day gastric ulcerogenicity was assessed by using macroscopic and microscopic scoring of ulcers.

Results: Diclofenac, nimesulide and thia 2 reduced both paw edema and peritoneal exudate volume significantly (p <0.01). Wet weight of cotton pellets reduced significantly (p <0.01) by diclofenac, nimesulide and thia 2. Diclofenac (p <0.01) and thia 2 (p <0.05) reduced dry weight of cotton pellets significantly. nimesulide and thia-1 reduced it by 19.14% and 2.68% respectively and was considered statistically not significant (p>0.05). Nimesulide, thia-1 and thia-2 did not increase gastric ulcer score significantly (p >0.05). Diclofenac increased ulcer score significantly (p <0.01).

Conclusions: Thia-2 demonstrated significant anti-inflammatory activity in acute and chronic models. In addition to inhibition of cyclooxygenase pathway, PPAR agonistic activity may be involved in its anti-inflammatory activity.  No significant ulcerogenicity was observed on comparing with nimesulide and control. Further in-vitro and in-vivo studies are recommended to confirm the results of this study.


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How to Cite

N., S. M., V., S., & M., S. (2018). Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats. International Journal of Basic & Clinical Pharmacology, 8(1), 8–15.



Original Research Articles