Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats

Shiva Murthy N.; Srinivas V.; Shanthi M.

doi:10.18203/2319-2003.ijbcp20185155

Authors

Shiva Murthy N. Department of Pharmacology, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India
Srinivas V. Department of Pharmacology, Koppal Institute of Medical Sciences, Koppal, Karnataka, India
Shanthi M. Department of Pathology, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20185155

Keywords:

Anti-inflammatory, Diclofenac, Nimesulide, NSAIDs, Thiazolidine-4-ones, Ulcerogenicity

Abstract

Background: NSAIDS are associated with side effects and research should continue for developing safer drugs. This study aims to evaluate newer thiazolidine-4-ones for their anti-inflammatory and ulcerogenic activities in wister rats.

Methods: Five groups of wister rats, 6 in each were used. Anti-inflammatory and ulcerogenic activities of diclofenac (30mg/kg), nimesulide (50mg/kg), thia-1 (50mg/kg) and thia-2 (50mg/kg) are compared with control group (4% Gum Acacia). Carrageenin-induced paw edema, formaline induced acute peritonitis and cotton pellet-induced granulomatous tissue formation models were used for evaluating anti-inflammatory activity. After removing cotton pellets with granuloma on 8^th day gastric ulcerogenicity was assessed by using macroscopic and microscopic scoring of ulcers.

Results: Diclofenac, nimesulide and thia 2 reduced both paw edema and peritoneal exudate volume significantly (p <0.01). Wet weight of cotton pellets reduced significantly (p <0.01) by diclofenac, nimesulide and thia 2. Diclofenac (p <0.01) and thia 2 (p <0.05) reduced dry weight of cotton pellets significantly. nimesulide and thia-1 reduced it by 19.14% and 2.68% respectively and was considered statistically not significant (p>0.05). Nimesulide, thia-1 and thia-2 did not increase gastric ulcer score significantly (p >0.05). Diclofenac increased ulcer score significantly (p <0.01).

Conclusions: Thia-2 demonstrated significant anti-inflammatory activity in acute and chronic models. In addition to inhibition of cyclooxygenase pathway, PPAR agonistic activity may be involved in its anti-inflammatory activity. No significant ulcerogenicity was observed on comparing with nimesulide and control. Further in-vitro and in-vivo studies are recommended to confirm the results of this study.

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