Drug utilization pattern of antimicrobials use in upper respiratory tract infection in paediatric patient of rural tertiary care hospital
Keywords:Antimicrobial, Infection, Sensitivity
Background: Antimicrobial agents (AMAs) are most commonly prescribed drugs for lower respiratory tract infection (LRTI). This study was conducted to evaluate pattern of prescription and AMAs use in paediatric patient for LRTI in wards of rural tertiary care teaching hospital.
Methods: This is prospective, observational study undertaken in paediatric patient in tertiary care hospital. Prescriptions of 60 patient of age group 1-12years diagnosed with LRTI admitted in paediatric ward of rural tertiary care teaching hospital were studied. Positive blood sample were studied for common microorganisms, their sensitivity and resistance to AMAs.
Results: Out of 60 patients admitted in paediatric ward of LRTI, 12 patients were of mild to moderate pneumonia, three patients were of bronchiolitis, ten patients were of croups, three patients were of bronchitis and 37 patients were of severe pneumonia. The most frequently prescribed AMAs were combination of cephalosporin and aminoglycosides. The most common organism isolated was streptococcus pneumoniae sensitive to vancomycin in 92.3% and meropenem in 84.6%, resistant to ampicillin, amoxicillin and cloxacillin in 92.3% of cases.
Conclusions: The study shows utilisation pattern of AMAs in LRTI, prescribing on which future intervention studies may be based to promote rational drug use.
Chang AB, Chang CC, O'Grady K, Torzillo PJ. Lower respiratory tract infections. Pediatr Clin. 2009 Dec 1;56(6):1303-21.
Lanata CF, Rudan I, Boschi-Pinto C, Tomaskovic L, Cherian T, Weber M, et al. Methodological and quality issues in epidemiological studies of acute lower respiratory infections in children in developing countries. Int J Epidemiol. 2004 May 27;33(6):1362-72.
Bradley JS, Byington CL, Shah SS, Alverson B, Carter ER, Harrison C, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infectious Dis. 2011 Oct 1;53(7):e25-76.
Francis BV, Abhilash TG. Study of acute respiratory tract infections in children. Int J Sci Res. 2016; 5(9):1791-2.
Grant CC, Scragg R, Tan D, Pati A, Aickin R, Yee RL. Hospitalisation for pneumonia in children in Auckland, New Zealand. J Paediatr Child Health. 1998 Aug;34(4):355-9.
Wattal C, Goel N, Oberoi JK, Raveendran R, Datta S, Prasad KJ. Surveillance of multidrug resistant organisms in tertiary care hospital in Delhi, India. J Assoc Physicians India. 2010 Dec;58(Suppl):32-6.
Sachdeva PD, Patel BG. Drug utilization studies-scope and future perspectives. Int J Pharmaceut Biol Res. 2010;1(1):11-7.
Palikhe N. Prescribing pattern of antibiotics in pediatric hospital of Kathmandu valley. J Nepal Health Res Council. 2004 Jan; 2(2):31-6.
Abramczyk ML, Carvalho WB, Carvalho ES, Medeiros EA. Nosocomial infection in a pediatric intensive care unit in a developing country. Brazilian J Infectious Dis. 2003 Dec;7(6):375-80.
Ilia S, Spanaki AM, Geromarkaki E, Filippou O, Briassouli E, Fitrolaki DM, et al. Contribution to mortality and resource usage of nosocomial and community infections in an intensive care setting. Arch Int J Med. 2009 Oct 1;2(4).
File Jr TM. Streptococcus pneumoniae and community-acquired pneumonia: a cause for concern. Am J Med Supplements. 2004 Aug 2;117(3):39-50.
Gajbhiye V, Kale R, Vilhekar K, Bahekar S. Drug utilization study on antimicrobials use in lower respiratory tract infection in Pediatric Intensive Care Unit of Rural Tertiary Care Hospital. J Med Society. 2016 Sep 1;30(3):146.