Comparative study of analgesic effect of Moringa oleifera leaf extracts with aspirin on experimental animals

Prashanth Kumar Patnaik; Mohammed Abdul Majeed; Bhuvaneshwari .; Laksmi Kameswari; M. B. Niharika

doi:10.18203/2319-2003.ijbcp20184196

Authors

Prashanth Kumar Patnaik Department of Pharmacology, Mahavir Institute of Medical Sciences, Vikarabad, Telangana, India
Mohammed Abdul Majeed Department of Pharmacology, Mahavir Institute of Medical Sciences, Vikarabad, Telangana, India
Bhuvaneshwari . Department of Pharmacology, Osmania Medical College, Hyderabad, Telangana, India
Laksmi Kameswari Department of Pharmacology, RIMS, Nizamabad, Telangana, India
M. B. Niharika Department of Pharmacology, Mahavir Institute of Medical Sciences, Vikarabad, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20184196

Keywords:

Aqueous extract of Moringa oleifera, Analgesics, Eddy′s hot plate method, Ethanolic extract of Moringa oleifera, Moringa oleifera

Abstract

Background: Moringa oleifera is highly valued with a wide range of medicinal uses. It is abundantly available in tropical and sub-tropical countries. It has been used as an analgesic and anti-inflammatory in Indian folk medicine since centuries. The mechanism of action of analgesic effect is by the phytochemical components of its leaves which contain alkaloids, glycosides, phenols, saponins and tannin.

Methods: This experiment is carried out in mice by using the thermal method of analgesiometer, that is Eddy’s Hot Plate method. Thermostatically controlled electrically heated plate is used in this method. Ethanolic and aqueous extracts of Moringa oleifera leaf extracts are compared with aspirin.

Results: When the analgesic properties of the standard drug aspirin were compared to the analgesic properties of ethanolic and aqueous extracts of Moringa oleifera, the ethanolic extract showed a comparable analgesic effect with aspirin at 90min. Among these two extracts, the ethanolic extract showed a higher response than aqueous extract.

Conclusions: When the analgesic properties of the standard drug aspirin were compared to the analgesic properties of ethanolic and aqueous extracts of Moringa oleifera, the ethanolic extract showed a comparable analgesic effect with aspirin at 90min. Among these two extracts, the ethanolic extract showed a higher response than aqueous extract.

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