Immunosuppressant effect of Boswellia serrata extract on CFA induced arthritis in rats

Sarvesh Singh; Rajendra Kumar; Anil Kumar Saksena; Rishi Pal; Riddhi Jaiswal; Rahul Kumar

doi:10.18203/2319-2003.ijbcp20183924

Authors

Sarvesh Singh Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Rajendra Kumar Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Anil Kumar Saksena Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Rishi Pal Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Riddhi Jaiswal Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Rahul Kumar Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20183924

Keywords:

Boswellia serrata extract, Complete Freund’s adjuvant, Cyclophosphamide, Rheumatoid arthritis

Abstract

Background: Rheumatoid arthritis (RA) is an immune-mediated arthropathy, so for the treatment disease modifying antirheumatoid drugs are required. In this study we are evaluating the immunomodulatory property of Boswellia serrata extract (BSE) as an alternative medicine.

Methods: Complete Freund’s adjuvant (CFA), 0.1ml was injected intradermally in the footpad of left hind paw in 36 Wistar rats to induce RA. Animals were divided into 6 groups. BSE in the doses of 45mg/kg, 90mg/kg and 180mg/kg was administered and cyclophosphamide as standard drug. Various parameters as body weight, paw thickness, ankle diameter, paw volume, arthritis index, TNF- α and histopathological changes were analyzed.

Results: Marked reduction in paw thickness, ankle diameter, paw volume, arthritis index and an improved body weight was found in high dose BSE (180mg/kg) group but the effect was lesser than standard drug Cyclophosphamide.

Conclusions: BSE has significant potential as an alternative medicine for treatment of autoimmune diseases like rheumatoid arthritis.

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