Efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced albino mice

Janardhan Marupaka; Roopa B.; Naveen Kumar T.

doi:10.18203/2319-2003.ijbcp20183942

Authors

Janardhan Marupaka Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences (RIMS), Adilabad, Telangana, India
Roopa B. Department of Pharmacology, RVM Institute of Medical Sciences and Research Centre, Laxmakkapally, Mugulu, Medak, Telangana, India
Naveen Kumar T. Department of Pharmacology, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20183942

Keywords:

Antidepressant activity, Albino mice, Ondansetron, Physical induced

Abstract

Background: The objective of this study was to evaluate efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced swiss albino mice.

Methods: Study was placebo controlled, randomized laboratory based comparative study with prior permission of Institutional animal ethical committee. Experimental animals were divided in to seven groups as control (distilled water 10ml/kg), standard Fluoxetine two doses (10mg/kg and 20mg/kg) , test drug ondansetron three doses (0.5mg/kg, 1mg/kg and 2mg/kg) and combinations of test and standard (0.5mg/kg + 10mg/kg).The drugs were administered intraperitonium and antidepressant activity was recorded using physically induced depression models tail suspension test and despair swim test.

Results: Ondansetron treated albino mice groups with dose dependent increase of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg showed significant decrease in antidepressant activity and increase in catalepsy score when compared with fluoxetine 10mg/kg and 20mg/kg. Combination doses showed stastically significant antidepressant activity.

Conclusions: The present study indicates ondansetron showed promising antidepressant activity due to its ability to modulate serotonergic system and has proved to be safe in the dose range of 0.5mg/kg, 1mg/kg and 2mg/kg in mice.

Metrics

Metrics Loading ...

References

Maxine A, Papadakis, Stephen JM. Mood disorders. In: Current Medical Diagnosis and Treatment, 55th Ed. New Delhi. McGraw Hill Education; 2016:1057.

Martin P, Gozlan H, Puech AJ. 5-HT3 receptor antagonists reverse helpless behaviour in rats. Eur J Pharmacol. 1992 Feb 25;212(1):73-8.

Ramamoorthy R, Radhakrishnan M, Borah M. Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models. Behavioural Pharmacol. 2008 Feb 1;19(1):29-40.

Kalra BS, Tayal V, Chawla S. Antidepressant-like activity of tramadol in mice. Indian J Psychiatry. 2008 Jan;50(1):51.

Vogel HG. Antidepressant activity. Drug Discovery and Evaluation: Pharmacological Assays, edited by Vogel HG, 2nd Ed. Germany: Springer - Verlag Berlin Heidelberg; 2002.

Greenshaw AJ. Behavioral pharmacology of 5HT3 receptor antagonist: acritical uptake on therapeutic potential. Trends Pharmacol Sci. 1992;14:265-70.

Bétry C, Etiévant A, Oosterhof C, Ebert B, Sanchez C, Haddjeri N. Role of 5-HT3 receptors in the antidepressant response. Pharmaceuticals. 2011 Apr 7;4(4):603-29.

Blandina PA, Goldfarb JO, Walcott JA, Green JP. Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices. J Pharmacol Experiment Therapeut. 1991 Jan 1;256(1):341-7.

Zifa E, Fillion G. 5HT receptors. Pharmacol Rev. 1992;44:401-58.

Tripathi KD. Antiemetic, Prokinetic and digestant drugs. Essential of Medical Pharmacology. 8th Ed. New Delhi. Jaypee Brothers medical publishers;2018:716-717.