Evaluation of learning and memory effect of atorvastatin and simvastatin in alprazolam induced amnesia in mice


  • Shashikala G. Department of Pharmacology, JJM Medical College, Davangere, Karnataka, India
  • Jyothi C. H. Department of Pharmacology, JJM Medical College, Davangere, Karnataka, India
  • Shashikala G. H. Department of Pharmacology, JJM Medical College, Davangere, Karnataka, India




Atorvastatin, Alprazolam, Alzheimer’s disease, Piracetam, Simvastatin


Background: The study was undertaken to evaluate the learning and memory effect of lipid lowering drugs atorvastatin and simvastatin in alprazolam induced amnesic mice.

Methods: The study was carried out on albino mice, divided into 4 groups of 6 animals each (either sex, 3-4 months of age, weight 25-30g). Amnesia was induced by administering Alprazolam (2mg/kg for 14 days) in all 4 groups from 1st to 14th day. In addition, group 2, 3 and 4 received Piracetam (400mg/kg), Atorvastatin (5mg/kg) and Simvastatin (5mg/kg) from 8th to 14th day respectively. The learning and memory of the animals was assessed by employing Elevated plus maze (EPM) and Step-down type passive avoidance (SDA) model.

Results: Results were compared among the different groups using one way-ANOVA followed by post hoc Tukey’s test. The measured parameters were compared with standard drug Piracetam. In EPM model Atorvastatin (p<0.049) and Simvastatin (p<0.007) were comparable with standard drug Piracetam, whereas in SDA model only simvastatin group (p<0.001) showed significant result.

Conclusions: In EPM model, both the statins showed significant improvement in learning and memory in alprazolam induced amnesic mice. However further studies are required to support these observations.


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How to Cite

G., S., C. H., J., & G. H., S. (2018). Evaluation of learning and memory effect of atorvastatin and simvastatin in alprazolam induced amnesia in mice. International Journal of Basic & Clinical Pharmacology, 7(10), 1900–1904. https://doi.org/10.18203/2319-2003.ijbcp20183920



Original Research Articles