A single compartment simulation model of pharmacokinetics

Harsh V. Salankar; Sonali B. Rode; Vinayak H. Bhavsar

doi:10.18203/2319-2003.ijbcp20183949

Authors

Harsh V. Salankar Department of Pharmacology, Shri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, India
Sonali B. Rode Department of Pharmacology, Shri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, India
Vinayak H. Bhavsar Department of Pharmacology, Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20183949

Keywords:

Elimination kinetics, Plasma half-life, Pharmacokinetics, Simulation model, Single compartment

Abstract

For better understanding about derivation of various parameters related to pharmacokinetics, this model is developed. Animals or human volunteers are not used in this model but the principles used in pharmacokinetic studies in volunteers are incorporated. There is detailed description about setting of the model and derivation of various parameters step by step. An example is followed to illustrate the calculations involved. Possibilities of further extension of model to derive additional parameters and variations are discussed. The experience indicates that the model serves as a good demonstration to undergraduate students and a meaningful experiment for PG-students for learning and as a practical-examination exercise. The purpose of the article is to widen the use of this simple teaching tool at various centers.

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