Preclinical HbA1c level studies of Brihat Khadir Batika and Chandraprabha Batika after chronic administration to male Sprague-Dawley rats

Umma Hafsa Asha; Nilay Saha; Md. Mamun Sikder; Khadija Akter; Tahmina Akter Sony; Md. Hasif Sinha; Md Mahabur Rahman; M. S. K. Choudhuri

doi:10.18203/2319-2003.ijbcp20184319

Authors

Umma Hafsa Asha Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Nilay Saha Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Md. Mamun Sikder Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Khadija Akter Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Tahmina Akter Sony Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Md. Hasif Sinha Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Md Mahabur Rahman Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
M. S. K. Choudhuri Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20184319

Keywords:

Ayurvedic preparations, Diabetes mellitus, HbA1c, Traditional medicines

Abstract

Background: Brihat Khadir Batika (BKD) and Chandraprabha Batika (CPB) are Ayurvedic preparations used as traditional medicines for different clinical indications in the rural population. BKD is used in diseases of throat and CPB is used in glandular enlargement. In this study we evaluate the influence of these preparations on HbA1c (%) level.

Methods: To find out the average plasma glucose concentration over prolonged period of time, Ayurvedic medicinal preparations BKD and CPB were administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/kg. After 28 days of chronic administration of BKD and CPB the following changes were noted. In this experiment Glycated Hemoglobin A1C level was determined.

Results: The results of the study of in vitro quantitative determination of rat Glycated hemoglobin A1c concentrations in serum studies are thus: BKD caused a statistically insignificant (p=0.066) increase in the HbA1c level of the male rat (16.87% increase). CPB demonstrated a statistically insignificant (p=0.079) (17.47%) increase in the HbA1C level of the blood of the male rat.

Conclusions: Both preparation BKD and CPB found in increasing HbA1c level of the blood of the male rat.

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