Drug utilization study of antihypertensive drugs used in the treatment of second and third trimester of pregnancy in tertiary care hospital

Shrikant B. Lahamate, Syed U. Razvi, Mirza S. Baig, Sudhakar M. Doifode


Background: Hypertensive disorders are major cause of the perinatal and maternal mortality and morbidity worldwide. Aim of study was to evaluate current trend of antihypertensive drugs and to assess frequency and distribution of antihypertensive drugs in pregnancy.

Methods: A retrospective observational study was conducted in a tertiary care hospital for period of six months in collaboration with department of obstetrics and gynaecology. Patients data recorded in case report form and analysed to study prescription pattern and related information.

Results: Total of 104 cases were enrolled in this study. Prescribed antihypertensive drugs in pregnancy were Labetalol, Nifedipine, MgSO4 and furosemide. Most commonly prescribed drug was labetalol. In this study, Gestational hypertension was most common diagnosis in hypertensive disorder. Majority of drug prescribed from category C and A. In present study, Single drug therapy was most commonly prescribed for hypertension in pregnancy was 64.42% whereas multiple drug therapy was 35.57%. Most common maternal complication was anaemia i.e. 54.05% followed by placental abruption in 24.3%. Neonatal outcome was low birth weight i.e.36% followed by preterm birth i.e.24%.

Conclusions: Labetalol found to be most common prescribed drug. Single drug therapy prescription was high as compared to multiple drug therapy prescription in hypertensive disorders in pregnancy. Gestational hypertension was most common cause of hypertensive disorder. Anaemia was found to be most common maternal complication encountered in hypertensive disorders in pregnancy. Most common adverse neonatal outcome was low birth weight.


Antihypertensive drugs, Drug utilization study, Gestational hypertension, Labetalol, Pregnancy

Full Text:



Abubakar K, Adbulkadir R, Abubakar SB, Jomih AO, Ugwah-Oguejiofor JC, Danzaki AM. Drug utilization pattern in pregnancy in a tertiary hospital in Sokoto, North West. J Heal Sci [Internet]. 2014;4(4):99-104. Available at:

Hooli TV, Santoshkumar J, Manjunath S, Vinodkumar CS. Drug utilization study of antihypertensives in obstetric practice in a tertiary care hospital Objectives. To evaluate the drug utilization of antihypertensive in obstetric practice two tertiary care hospitals in Gulba. 2010;I(3):1006-10.

Bhagat SB, Patil KC. International Journal of Research in Analysis of the current trend in the prescription of anti-hypertensive drugs among pregnant females in a tertiary care hospital. 2014;3(4):358-65.

Folic M, Folic N, Varjacic M, Jakovljevic M, Jankovic S. Review article Antihypertensive drug therapy for hypertensive disorders in pregnancy. Acta Medica Median. 2008;47(3):65-72.

Hypertension G, Blockers CC, Blocker AR. A study on prescribing pattern of antihypertensive drugs during pregnancy in tertiary care hospital, Bangalore. Anju AS, Peter Kandel, Dr. Praveen Kumar, K. Ramkumar, Dr. B. A Viswanath. 2016;6(09).

Bozzuto G, Ruggieri P, Molinari A. Molecular aspects of tumor cell migration and invasion. Annali dell'Istituto superiore di sanitÃ. 2010;46:66-80.

Patel R, Baria H, Patel HR, Nayak S. A study on pregnancy induced hypertension and foetal outcome among patient with PIH at tertiary care hospital, Valsad. 2017;4(11):4277-81.

Moser M, Brown CM, Rose CH, Garovic VD. Hypertension in pregnancy: Is it time for a new approach to treatment? J Hypertens. 2012;30(6):1092-100.

Gaidhankar SL, Pore SM, Deokate MN, Ramanand SJ, Salunke AT. A study of drug utilization in indoor patients of high-risk pregnancy in a tertiary care hospital. Int J Basic Clin Pharmacol. 2016;5(4):1366-71.

Yadav S, Evangeline GS. a Study on Prescribing Patterns of Drugs in Pregnant Women Attending a Teaching Hospital. 2016;6(1):9-26.

Sharma R, Kapoor B, Verma U. Drug utlization patten during pregnancy in north India. Indian J Med Sci. 2006;60(7):277-86.

Sarita J, Bhupinder B. Evaluation of Antihypertensive Therapy of Pregnancy Induced Hypertensive (Pih) Patients in Mahila Chiktsalaya, Jaipur. 2011;2(1):5-10.

Kumar TN, Tadvi NA, RK. Prescription pattern of drugs in pregnancy induced hypertension in a tertiary care hospital. Int J Basic Clin Pharmacol [Internet]. 2013;2(6):783. Available at:

Sajith M, Nimbargi V, Modi A, Sumariya R. Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy. Intranational J pharma Sci Res. 2014;5(04):163-70.

Jagadeesh K, Doctor M. Research Article Drug Utilization Evaluation in Diabetic Patients in a Tertiary Care Teaching Hospital: A Prospective Observational Study. 2014;4(5):147-51.