DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20160752

Prescribing pattern of antimicrobials in various clinical departments of a tertiary care hospital

Rohith V., Manjunatha C. H., Anusha N., Jayasheela J., Isabella Topno

Abstract


Background: Antimicrobials are one of the most commonly used group of drugs. Their overuse and inappropriate use is one of the major concerns today. Assessment of prescribing pattern of antimicrobials provides insight into the health consequences and helps update antimicrobial usage guidelines. Hence this study was conducted with an objective to analyse the prescribing pattern of the antimicrobials.

Methods: A cross sectional study was conducted based on the prescriptions collected from Department of Pharmacy, Pondicherry Institute of Medical Sciences (PIMS), Puducherry. A total of 838 outpatient prescriptions were collected from four clinical departments, viz. General Medicine, General Surgery, Pediatrics and Obstetrics & Gynecology for a period of four months. The data collected were analysed using descriptive statistics.

Results: Among 838 prescriptions 188 (22.43%) contained antimicrobials. Among the various departments, number of prescriptions with antimicrobials were more in department of General surgery (34.42 %) followed by Obstetrics & Gynecology (24.77 %). The commonly prescribed antibiotics were penicillins (25.47%), fluoroquinolones (12.73%), cephalosporins (10.84%), macrolides (8.96%), nitroimidazoles (6.60%) and tetracyclines (4.71%). Among the total antimicrobials, percentage of drugs prescribed by generic name and from National list of essential medicines (NLEM) were 38.20% and 80.18% respectively. Majority of antimicrobials (58.01%) were prescribed as oral tablets/ capsules.

Conclusions: It was found that penicillins were the most commonly prescribed group of antimicrobials, significantly less number of antimicrobials were prescribed by generic name, 80.18% of antimicrobials were prescribed from NLEM and tablets/ capsules were the most common dosage forms.


Keywords


Antimicrobials, Prescribing pattern, Generic name

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References


Zhou MS, Wang A, Yu H. Link between insulin resistance and hypertension: what is the evidence from evolutionary biology? Diabetology & Metabolic Syndrome. 2014;6(12):1-8.

Davies DS, Watson J, Shallcross L. A global overview of Antimicrobial resistance. AMR Control 2015. Woodbridge, UK: Global health dynamic. 2015:12-16.

WHO. Global strategy for the containment of antimicrobial resistance. Geneva: World Health Organization. 2001. Available from URL: http://www.who.int/ emc/amr_interventions.htm. Accessed 24 Dec 2015.

Webster PC. Leaked internal report criticizes government oversight of antimicrobial resistance. CMAJ. 2011;183(10):E641-2.

Chunhui Li, Nan Ren, Ximao Wen, Pengcheng Zhou, Xun Huang, Ruie Gong et al. Changes in Antimicrobial Use Prevalence in China: Results from Five Point Prevalence Studies. PLOS ONE. 2013;8(12):1-6.

Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742-50.

Adhikari A, Singh S, Bhowal T, Biswas S, Banerjee S, Ray M, et al. Study of prescribing pattern of antimicrobial agents in selected patients attending tertiary care hospital in India. Explor Anim Med Res. 2013;3:29-35.

Prasad PS, Rudra JT, Vasanthi P. Assessment of drug use pattern using World Health Organization core drug use indicators at Secondary Care Referral Hospital of South India. CHRISMED Journal of Health and Research. 2015;2(3):223-28.

Desalegn AA. Assessment of drug use pattern using WHO prescribing indicators at Hawassa University teaching and referral hospital, south Ethiopia: a cross-sectional study. BMC Health Services Research. 2013;13:170.

Masterton R. The importance and future of antimicrobial surveillance studies. Clinical infectious diseases. 2008;47(1):S21-31.

Alan J, Wright MD. The penicillins. Mayo Clinic Proceedings; 1999;74(3):293-307.

World Health Organization. 1993. How to Investigate Drug Use in Health Facilities. WHO/DAP/93.1, WHO, Geneva.

Mittal N, Mittal R, Singh I, Shafiq N, Malhotra S. Drug utilisation study in a tertiary care center: Recommendations for improving hospital drug dispensing policies. Indian journal of pharmaceutical sciences. 2014;76(4):308.