The protective effect of L. siceraria against depression using behavioural despair animal models


  • Karunakar Kota Department of Pharmacology, Government Medical College, Pali, Rajasthan, India
  • Sandhya Sharma Department of Physiology, American International Institute of Medical Sciences, Udaipur, Rajasthan, India
  • P. Ragavendra Department of Analytical Research and Development, Sai Life Sciences Ltd, Laboratory No. 10, IKP road, Turkapally, Medhak, Telangana, India
  • Jameela Tahashildar Department of Pharmacology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India



Antidepressant activity, Behavioural despair, Forced swim test, Imipramine, Lagenaria siceraria, Tail suspension test


Background: In recent years, the search for novel pharmacotherapy from medicinal plants for psychiatric illness was significantly progressed. The present study was performed to evaluate the antidepressant activity of ethanolic extract of Lagenaria siceraria in animal models.

Methods: The antidepressant activity of ethanolic extract of the fruit of L. siceraria in rats was assessed using forced swim test and tail suspension test. Imipramine at 15 mg/kg was used as standard antidepressant drug.

Results: The ethanolic extract of L. siceraria fruit (EELS) was significantly and dose-dependently reduced the duration of immobility after repeated treatment for 7 days in Forced swim test and Tail suspension Test. But combination of L. siceraria (200mg/kg) with Imipramine gave a highly significant result (p<0.001) in reduction of immobility duration and the effect of high dose (400mg/kg) with imipramine (15mg/kg) did not decrease the duration of immobility period in both animal models at end of the study. In this work the dose of 400mg/kg afforded more protection than the imipramine.

Conclusions: The results obtained from this study was indicate that the antidepressant activity of L. siseraria.


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How to Cite

Kota, K., Sharma, S., Ragavendra, P., & Tahashildar, J. (2018). The protective effect of L. siceraria against depression using behavioural despair animal models. International Journal of Basic & Clinical Pharmacology, 7(7), 1391–1395.



Original Research Articles