Evaluation of antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino wistar rats

Abhijith L. M.; Ravi K. Sori

doi:10.18203/2319-2003.ijbcp20182686

Authors

Abhijith L. M. Department of Pharmacology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India
Ravi K. Sori Department of Pharmacology, SDM College of Medical Sciences & Hospital, Dharwad, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20182686

Keywords:

Alloxan, Glibenclamide, Hypoglycaemia, Tinospora cardifolia

Abstract

Background: The objective was to evaluate the antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino rats in comparison with a currently used oral hypoglycaemic glibenclamide.

Methods: there were 24 rats with FBS in the range 80-115 mg/dl were selected for the study. Four groups each containing six rats, were induced diabetes with alloxan (150mg/kg). The diabetic control group (0.5ml normal saline), Standard control group (5mg/kg glibenclimide), Test group I (200mg/kg T. cardifolia) and test II group 400mg/kg T. cardifolia). FBS was recorded on 1, 3, 7, 14, 21 and 28^th day using glucometer. Data was analysed by using one way ANOVA and posthoc Tukey’s test SPSS 21Version.

Results: Extract of Tinospora cardifolia showed dependent hypoglycaemic action in both low dose (200mg/kg) and high dose group (400mg/kg). Hypoglycaemic action with high dose of Tinospora cardifolia is comparable to that of standard drug glibenclamide.

Conclusions: This study demonstrates the hypoglycaemic action of T. cardifolia in diabetic rats. T. cardifolia can be a therapeutic potential to treat type 2 diabetes mellitus.

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