Evaluation of antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino wistar rats
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20182686Keywords:
Alloxan, Glibenclamide, Hypoglycaemia, Tinospora cardifoliaAbstract
Background: The objective was to evaluate the antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino rats in comparison with a currently used oral hypoglycaemic glibenclamide.
Methods: there were 24 rats with FBS in the range 80-115 mg/dl were selected for the study. Four groups each containing six rats, were induced diabetes with alloxan (150mg/kg). The diabetic control group (0.5ml normal saline), Standard control group (5mg/kg glibenclimide), Test group I (200mg/kg T. cardifolia) and test II group 400mg/kg T. cardifolia). FBS was recorded on 1, 3, 7, 14, 21 and 28th day using glucometer. Data was analysed by using one way ANOVA and posthoc Tukey’s test SPSS 21Version.
Results: Extract of Tinospora cardifolia showed dependent hypoglycaemic action in both low dose (200mg/kg) and high dose group (400mg/kg). Hypoglycaemic action with high dose of Tinospora cardifolia is comparable to that of standard drug glibenclamide.
Conclusions: This study demonstrates the hypoglycaemic action of T. cardifolia in diabetic rats. T. cardifolia can be a therapeutic potential to treat type 2 diabetes mellitus.
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References
American diabetic association. Diagnosis and classification of diabetes mellitus. Diabetic Care. 2005;28(1):S37-S42.
Park K. Park’s textbook of preventive and social medicine. 19th Edn. Jabalpur: Banarasidas Bhanot;2005:327-332.
Kasper DL, Braunwald E, Fauci AS, Hauser AL, Longo DL, Jameson JL, editors. Harrison’s principles of internal medicine, vol.2, 16th Edn., Newyork, McGraw Hill;2005:2152-2179.
Babu V, Gangadevi T, Subramaniam A. Antihyperglycemic activity of cassia Kleinii leaf extract in glucose fed normal rats and alloxan induced diabetic rats. Indian J Pharmacol. 2002;34;409-15.
Sivakumar V, Dhanarajan MS, Hypoglycemic and antioxidant activity of Tinospora cordifolia in experimental diabetes. IJPSR. 2011;2(3):608-13.
Dunn JS, Mcletchie NG. Experimental alloxan diabetes in the rat. Lancet. 1943;245:484-7.
Krishna KL, Jigar B, Jagruti P. Guduchi (Tinospora cordifolia): Biological and Medicinal properties: A review. Internet J Altern Med. 2009;6:2.
Sivakumar V, Mohamed Sadiq A. Hypoglycemic Activity of Tinospora cordifolia in Alloxan induced diabetic rats. The Bioscan 2009;4(1):75-8.
Grover JK, Rathi SS, Vats V. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens and Tinospora cordifolia) extracts. Indian J Exp Biol. 2002;40:273-6. [PubMed]