Evaluation of hepatoprotective activity of aqueous extract of ricinus communis in Wistar rats

Authors

  • Naveen A. Department of Pharmacology,Mamata Medical College,Khammam, Telangana, India
  • Shankar J. Microtherapeutic Research Labs Pvt Ltd., Chromepet, Chennai, Tamilnadu, India
  • Premendran John Department of Pharmacology,Mamata Medical College,Khammam, Telangana, India
  • Venkatanarayana N. Department of Pharmacology,Mamata Medical College,Khammam, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20160744

Keywords:

Carbon tetrachloride, Hepatoprotective activity, Ricinus communis

Abstract

Background: The aim of the present study was to evaluate hepatoprotective activity of aqueous extract of ricinus communis in wistar rats.

Methods: Liver, the key organ of metabolism and excretion, is constantly endowed with the task of detoxification of xenobiotics, environmental pollutants and chemotherapeutic agents. The animals were divided into six groups with six rats in each group. First group were taken as control, and they received 0.9% normal saline 10ml/kg body weight orally. Second group was taken as CCl4 control group and treated with normal saline (10 ml/ kg, p.o.) and CCl4: olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8th day) daily for 20 day. The third group of six rats were treated with Liv 52- 100 mg/kg orally and CCl4: olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8th day) for 20 days .The fourth and fifth groups were taken as test groups and they received crude extract of ricinus communis orally once daily for 20 days at the dosage of 250 and 500mg/kg respectively. CCl4: olive oil was given i.p on 2, 5 and 8th day. On the 21stday, blood samples were collected by cardiac puncture method. The blood samples were used estimate biochemical parameters like serum AST and ALT.

Results: It was found that the ricinus communis at the doses of 250 and 500mg/kg exhibited moderate protective effect by lowering the serum levels of ALT and AST (P<0.001).

Conclusions: Ricinus communis has dose dependant hepatoprotective activity.

References

Said HM. Medicinal Herbal. Karachi: Baital Hikmah at Madinatal-Hikmah. 1996:215-17.

Philipson JD. Natural products as a basis for new drugs Trends. Pharmacol. Sci. 1989;1:36-8.

Singh S, Mehta A, Mehta P. Hepato protective Activity of Cajanus cajana Against Carbon Tetrachloride Induced Liver Damage. International Journal of Pharmacy And Pharmaceutical Sciences. 2011;3(2):146-7.

Gond. Hepatoprotective Activity of Ficus carica Leaf Extract, Indian J Pharm Sci. 2008;70(3):364-6.

Euphorbiaceae (spurge) genomics. Institute for Genome Sciences. University of Maryland Medical School. Retrieved. 2009;3:9.

Oyewole OI, Owoseni AA, Faboro EO. Studies on medicinal and toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris leaf extracts. Journal of Medicinal Plant Research. 2010;4(19):2004-8.

Williamson EM. (ed) Major Herbs of Ayurveda Churchill Livingstone. 2002.

Lomash V, Parihar SK, Jain NK, Katiyar AK. Effect

of Solanum nigrum and Ricinus communis extracts on histamine and carrageenan-induced inflammation in the chicken skin. Cellular and molecular biology (Noisy-le-Grand, France). 2010;56:1239-51.

Johnston DE, Kroening C. Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes. Pharmacol Toxicol. 1998;83(6):231‐9.

Singh S, Mehta A, Mehta P. Hepato protective activity of Cajanus cajana carbon tetrachloride induced liver damage. International journal of pharmacy and pharmaceutical sciences. 2011;3(2):146-7.

Mehta RS, Shankar MB, Geetha M, Saluja AK. Hepato protective activity of Trianthema portulacastrum. Indian drugs. 1999;36(4):241-3.

Vesen PKS, Shukla B, Patnayak GK, Tripathi SC. Hepato protective activity of Ricinus communis leaves. Pharmaceutical Biology. 1992;30(4):241-50.

Princea ES, Parameswarib P, Khan RM. Protective effect of Ricinus communis leaves extract on carbon tetrachloride induced hepatotoxicity in albino rats. Iranian Journal of Pharmaceutical Sciences. 2011;7(4):269-7.

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Published

2016-12-28

How to Cite

A., N., J., S., John, P., & N., V. (2016). Evaluation of hepatoprotective activity of aqueous extract of ricinus communis in Wistar rats. International Journal of Basic & Clinical Pharmacology, 5(2), 358–361. https://doi.org/10.18203/2319-2003.ijbcp20160744

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Original Research Articles