Drug utilization study in postoperative patients in obstetrics and gynaecology ward of tertiary care hospital


  • Rajeshwari . Department of Pharmacology, Mandya institute of Medical sciences, Mandya, Karnataka, India
  • Nagabushan H. Department of Pharmacology, Mandya institute of Medical sciences, Mandya, Karnataka, India




Drug utilization, Post-operative, Obstetrics and gynaecology


Background: A growing number of pharmaceutical products are available in the world market and there has been an increase both in the consumption of the drugs and in expenditure on them. The aim of the study was to analyse drug usage in post-operative patients in obstetrics and gynaecological ward and to assess the prescribing indicators (WHO: Core Drug Use Indicators).

Methods: A prospective observational study was conducted over a period of six months, after getting approval from Institutional Ethics committee. A specially designed proforma was used to collect the data of post-operative patients in Obstetrics and Gynaecological ward of a tertiary care hospital. The data was analysed using descriptive analysis with the help of SPSS software.

Results: A total of 582 cases were analysed during the study. Out of 582 patients, 559 (96%) were prescribed with parenteral cefotaxime and metronidazole. Post-operative pain was managed with tramadol (96%). All patients were prescribed with an antibacterial agent and analgesic (100%). The percentage of encounters with an injection prescribed was 100% in our study. Out of 19 different drugs prescribed, 16 (84.21%) were from the Essential Medicines WHO Model List (2015) and 10 (52.63%) were prescribed by their generic name.

Conclusions: The present study provides valuable insight about the overall pattern of drug used in postoperative patients. The study is useful in decreasing the irrational prescription, which helps to decrease the morbidity and health care burden in the society.


Fourth Report of WHO Expert committee: The use of essential drug, WHO TRS 796, World Health Organization; 1990. [Internet] 2012. [Cited March 2013]. Available from: www.who.int/iris/bitstream/10665/39338/1/WHO_TRS_796.pdf

Agrawal JM, Patel NM, Vaniya HV, Trivedi HR, Balat JD. Drug utilization study in post-operative patients in obstetrics and gynaecology ward of a tertiary care teaching hospital. J Clin Exp Res. 2014;2:103-109.

Shewade D, Pradhan S. Auditing of prescriptions in a government teaching hospital and four retail medical stores in Pondicherry. Indian J Pharmacol 1998;30:408-10.

Nausheen S. Rational use of antibiotics - a quality improvement initiative in hospital setting. Pak Med Assoc. 2013;63(1):60-4.

Falguni. Use of antimicrobial prophylaxis for obstetric and gynaecological surgeries and sensitivity pattern of infective organisms. World journal of pharmacy and pharmaceutical sciences. 2014;3(6):1170-80.

Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection. Centres for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. American Journal of Infection Control. 1999;27:97-132. http://dx.doi.org/10.1016/S0196-6553(99)70088-X.

Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. The New England Journal of Medicine. 1992;32:281-6.

Shankar PR, Partha P, Dubey AK, Mishra P, Deshpande VY. Univ Med J. 2005;3(2):130-7.

Bhansali NB. Drug utilization study in post-operative patients in surgical ward of a tertiary hospital attached with medical college. Der Pharmacia Lettre. 2013;5(1):251-7.

Lim VKE, cheong YM, Suleiman AB. Pattern of antibiotic usage in hospital in Malaysia. Singapore Med J. 1993;34:525-8.

Mc Donald LC, Yu HT, Yin HC, Hsiung AC, Ho M. Use and abuse of surgical antibiotic prophylaxis in hospital in Taiwan. J Formos Med Assoc. 2001;100:5-13.

Kunin CM, Lipton HL, Tupasi T, Sacks T, Schecker W. Social, behavioral and practical factors affecting antibiotic use worldwide. Report of task force 4. Rev Infect Dis. 1987;9(1):S270-S85.

Ledger WJ, Prophylactic antibiotics in obstetrics and Gynaeocology. A current asset, a future liability? Expert Rev Anti Infect Ther. 2006;4:957-64.

Gudiol F. Surgical antibiotic prophylaxis, tradition and change. Int J Clin Pract. 1998;95(1):398-438.

Shah BK, Shah VN. Antimicrobial use by Department of Obstetrics and Gynaecology of a tertiary care hospital: Analysis for rationality and other aspects. J Obstet Gynecol Ind. 2004;54(4):387-92.

Gyawali S, Shankar PR, Saha A, Mohan L. Study of prescription of injectable drugs and intravenous fluids to inpatients in a teaching hospital in Western Nepal. MJM. 2009;12:13-20.

Heethal. J. Pattern of antimicrobial use in caesarean

section in a tertiary care hospital in rural south

India. Int J Pharm Biomed Res. 2010;1(2):57-61.

Hutin Y. Recent progress towards the safe and appropriate use of injections worldwide. WHO Essential Drug Monitor. 2005;34:6-7.

Zamin HT, Pitre MM, Conly JM. Development of an intravenous to oral route conversion program for antimicrobial therapy at a Canadian tertiary health care facility. Ann Pharmacother. 1997;31:564-70.

Tabish A, Jha RK. Prescribing Trend of Analgesics in a Tertiary Health Care Setup of Rural Vidarbha: A Critical Appraisal. RJPBCS. 2012;3:566-71.

Bertolini G, Minelli C. The use of analgesic drugs in postoperative patients: the neglected problem of pain control in intensive care units. An observational, prospective, multicentre study in 128 Italian intensive care units. Eur J Clin Pharmacol. 2002;58:73-7.

Swamy RM, Venkatesh G, Nagaraj HK. A prospective drug utilization evaluation of analgesics and pain assessment in postoperative urological patients in a Tertiary care hospital. Biomedical Research. 2010;21(4):401-5.

Kolawole IK. Post-operative apin management following caesarean section in university of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria. WAJM. 2003;22(4):305-9.

Kumarasingam T. Drug utilization pattern of analgesics among postoperative patients in a tertiary care hospital. Der Pharmacia Lettre. 2014;6(3):40-6.

Ninth Report of the WHO expert committee: The use of Essential Drugs. WHO TRS 895. 2000.

Nineteenth WHO Model List of Essential Medicines. 2015. http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf.




How to Cite

., R., & H., N. (2016). Drug utilization study in postoperative patients in obstetrics and gynaecology ward of tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 5(2), 329–334. https://doi.org/10.18203/2319-2003.ijbcp20160740



Original Research Articles