Cure from the rhizomes: the medicine behind the Indian saffron Curcumin

Authors

  • Sujatha S. Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India
  • Priyadharshini R. Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India
  • Shwetha V. Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India
  • Yashoda Devi B. K. Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India
  • Pavan Kumar T. Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India
  • Rizwana Azmi Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20182087

Keywords:

Curcumin, Indian medicine, Oral Lesions, Turmeric

Abstract

Indian system of medicine has always focused on cure from the nature. Plant products from the Indian household have been used as medicine to cure myriad of ailments since ancestral times. Curcumin is a polyphenol, an active ingredient found in turmeric. In Southeast Asia, turmeric has been used as a coloring, flavoring and as a therapeutic agent. The use of turmeric to treat ailments dates back to the times of Charaka and Shushrutha. It has been widely used as an antiseptic for cuts, burns, and bruises, and as an antibacterial agent. Modern medicine has begun to understand its importance in recent times. Unfortunately its poor solubility, limited absorption and enhanced metabolism limits its bioavailability for its extended therapeutic use. Integration of nanotechnology in drug design and development has led the way to development of nanocurcumin with improved pharmacological properties. A precise understanding of effective dose, safety, and mechanism of action is required for the rational use of turmeric in the treatment of human diseases. This review focuses on the molecular actions of curcumin and its possibility to be used as a therapeutic agent in conditions affecting oral mucosa.

References

Premila MS. Ayurvedic herbs: a clinical guide to the healing plants of traditional Indian medicine. Psychology Press; 2006.

Seth SD, Sharma B. Medicinal plants in India. Indian J Med Res. 2004;120(1):9-11.

Walsh LJ. Back to the roots: Applications of curcumin (turmeric) in dentistry.

Sharma RA, Steward WP, Gescher AJ. Pharmacokinetics and pharmacodynamics of curcumin. InThe molecular targets and therapeutic uses of curcumin in health and disease 2007:453-470. Springer, Boston, MA.

Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr. 2004;44(2):97-111.

Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 2010;343(9):489-99.

Flora G, Gupta D, Tiwari A. Nanocurcumin: a promising therapeutic advancement over native curcumin. Crit Rev Ther Drug Carr Syst. 2013;30(4).

Rao S, Dinkar C, Vaishnav LK, Rao P, Rai MP, Fayad R, et al. The Indian spice turmeric delays and mitigates radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer: an investigational study. Integr Cancer Ther. 2014;13(3):201-10.

Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. 2013;180(1):34-43.

Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol. 2011;15(1):35.

Waghmare PF, Chaudhari AU, Karhadkar VM, Jamkhande AS. Comparative evaluation of turmeric and chlorhexidinegluconate mouthwash in prevention of plaque formationand gingivitis: a clinical and microbiological study. J Contemp Dent Pract. 2011;12(4):221-4.

Kia SJ, Shirazian S, Mansourian A, Fard LK, Ashnagar S. Comparative Efficacy of Topical Curcumin and Triamcinolone for Oral Lichen Planus: A Randomized, Controlled Clinical Trial. J Dent (Tehran). 2015;12(11):789.

Chainani-Wu N, Collins K, Silverman S. Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease. Phytomedicine. 2012;19(5):418-23.

Kuriakose MA, Ramdas K, Dey B, Iyer S, Rajan G, Elango KK, et al. A randomized double-blind placebo-controlled phase IIB trial of curcumin in oral leukoplakia. Cancer Prev Res. 2016;9(8):683-91.

Singh S, Singh R, Kamal V, Raj U, Nazeer J. Evaluation of Efficacy of Turmeric in Management of Oral Submucous Fibrosis. Imp J Interdiscip Res. 2017;3(5).

Yadav M, Aravinda K, Saxena VS, Srinivas K, Ratnakar P, Gupta J, et al. Comparison of curcumin with intralesional steroid injections in Oral Submucous Fibrosis–A randomized, open-label interventional study. J oral Biol craniofacial Res. 2014;4(3):169-73.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218.

Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R, Priyadarsini KI. Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta (BBA)-General Subj. 2008;1780(4):673-9.

Dovigo LN, Carmello JC, de Souza Costa CA, Vergani CE, Brunetti IL, Bagnato VS, et al. Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. Med Mycol Internet. 2013 Apr 1;51(3):243-51. Available at: http://dx.doi.org/10.3109/13693786.2012.714081

Martins CVB, Da Silva DL, Neres ATM, Magalhaes TFF, Watanabe GA, Modolo LV, et al. Curcumin as a promising antifungal of clinical interest. J Antimicrob Chemother. 2008;63(2):337-9.

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Published

2018-05-22

How to Cite

S., S., R., P., V., S., B. K., Y. D., T., P. K., & Azmi, R. (2018). Cure from the rhizomes: the medicine behind the Indian saffron Curcumin. International Journal of Basic & Clinical Pharmacology, 7(6), 1052–1056. https://doi.org/10.18203/2319-2003.ijbcp20182087

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Section

Review Articles