Prescribing pattern of oral anti-diabetic agents in type 2 diabetes mellitus patients in a tertiary care hospital
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20181642Keywords:
Oral anti-diabetic agents, Prescribing pattern, Type 2 diabetes mellitusAbstract
Background: Prescription pattern studies are a tool for assessing the prescribing, dispensing and distribution of medicines. The main aim of assessing prescribing pattern is to facilitate rational use of medicines. So the main aim of the study was to assess the prescribing pattern of oral anti-diabetic agents in type 2 diabetes mellitus, to assess the rationality of the prescribed drugs and also to assess the pattern of co-morbid conditions associated with type 2 diabetes mellitus in a tertiary care hospital.
Methods: This cross sectional study was conducted in the Department of Pharmacology in collaboration with Department of General Medicine. Study was conducted from 1st June 2016 to 31st Aug 2016 (3 months). A total of 100 patients were enrolled after taking written informed consent. A structured case recording form was used to record demographic details and prescription details. The rationality of prescriptions was assessed using American Diabetes Association guidelines 2015.
Results: Majority of the patients were prescribed combination therapy (54%) followed by monotherapy (46%). Oral anti-diabetic agents used as monotherapy other than metformin were inappropriate. Among the patients receiving combination therapy majority were receiving a fixed dose combination which were inappropriate.
Conclusions: Majority of the patients were receiving fixed dose combinations without justifiable pharmacokinetic/pharmacodynamic benefits. Such kinds of studies are required to improve rationality of prescription of drugs, decreasing morbidity and mortality of patients and decreasing the cost of treatment.
References
Ansari KU, Singh S, Pandey RC. Evaluation of prescribing pattern of doctors for rational drug therapy. Indian J Pharmacol. 1998;30:43-6.
Jain S, Upadhyaya P, Goyal J, Kumar A, Jain P, Seth V, et al. A systematic review of prescription pattern monitoring studies and their effectiveness in promoting rational use of medicines. Perspectives in Clinical Research. 2015;6(2):86-90.
Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward. M et al. Intensive Blood Glucose Control and Vascular Outcomes in patients with Type 2 Diabetes. NEJM. 2008;358:2560-72.
Unger J. Current strategies for evaluating, monitoring, and treating type 2 diabetes mellitus. Am J Med 2008;121(6 Suppl):S3-8.
American Diabetes Association. The pharmacological treatment of hyperglycemia in NIDDM. Diabetes Care. 1995;18:1510-8.
Meyer TA. Improving the quality of the order-writing process for inpatient orders and outpatient prescriptions. Am J Health-Syst Pharm. 2000;57 (Suppl 4):S18-22.
American Diabetes Association. Approaches to glycemic treatment. Diabetes Care. 2015;38:S41-8.
Medical Council of India. Code of ethics regulation 2002. Available at: http://www.mciindia.org/RulesandRegulations/CodeofMedicalEthicsRegulations2002.aspx/ accessed on 19th January 2016.
Haghighatpanah M, Thunga G, Jha A, Mallayasamy S. Study on prescribing pattern of anti-diabetic drugs among type 2 diabetes patients with complication in south indian teaching hospital. Asian J Pharm Clin Res. 2016;9(Suppl1):194-7.
Upadhyay DK, Palaian S, Shankar PR, Mishra P, Sah AK. Prescribing Pattern in Diabetic Outpatients in a Tertiary Care Teaching Hospital in Nepal. Journal of Clinical and Diagnostic Research. 2007;3:248-55.
Patel B, Oza B, Patel PK, Malhotra DS, Patel JV. Pattern of antidiabetic drugs use in type-2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2013;2(4):485-91.
Al Khaja KA, Sequeira RP, Mathur VS. Prescribing patterns and therapeutic implications for diabetic hypertension in Bahrain. Ann Pharmacother. 2001;35(11):1350-9.
Santra D, Totade S. Prescribing trends of antidiabetic fixed dose combination in a rural tertiary care teaching hospital in central India: An observational, cross sectional study. Research Journal of Pharmacology and Pharmacodynamics. 2015;7(1):19-22.
Agarwal AA, Jadhav RP, Deshmukh AY. Prescribing pattern and efficacy of anti diabetic drugs in maintaining optimal glycemic levels in diabetic patients. Journal of Basic and Clinical Pharmacy. 2014;5(3):79-83.